Ceefourin 1|cas:315702-40-0|西域试剂

Ceefourin 1,99.38%

产品编号：Bellancom-101453| CAS NO：315702-40-0| 分子式：C₁₁H₁₀N₄S₃| 分子量：294.42

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货号	价格	库存与货期
Bellancom-101453	￥1000.00	杭州北京（现货）
Bellancom-101453	￥1500.00	杭州北京（现货）
Bellancom-101453	￥3200.00	杭州北京（现货）
Bellancom-101453	￥5000.00	杭州北京（现货）
Bellancom-101453	￥9500.00	杭州北京（现货）

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Ceefourin 1

产品介绍

Ceefourin 1 是一种有效且高度选择性的多药抗性蛋白 4 (MRP4) 抑制剂。Ceefourin 1 抑制多种 MRP4 底物的转运，但对其他 ABC 转运蛋白没有选择性。Ceefourin 1 是一种苯并噻唑，主要用作高危神经母细胞瘤的化学增敏剂。

生物活性

Ceefourin 1 is a potent and highly selective multidrug resistance protein 4 (MRP4) inhibitor. Ceefourin 1 inhibits transport of a broad range of MRP4 substrates, yet is highly selective for MRP4 over other ABC transporters. Ceefourin 1 is a benzothiazol and primarily as a chemosensitizer for high-risk neuroblastoma.

体外研究

Ceefourin 1 are highly selective for MRP4 over other ABC transporters, including P-glycoprotein (P-gp), ABCG2 (Breast Cancer Resistance Protein; BCRP) and MRP1 (ABCC1). Ceefourin 1 has limited off-target effects and high stability.
Ceefourin 1 (100 nM-100 μM) has low cellular toxicity (IC₅₀>50) in two normal (HSF, MRC5), seven neuroblastoma (BE(2)-C, IMR-32, LAN-1, IMR-32, SK-N-SH, NBL-WN, SHEP) and four other human cancer cell lines (HEPG2, LNCap, SJ-G2, MCF7).
Ceefourin 1 has an IC₅₀ of 2.5 μM in HEK293 cell. Ceefourin 1 blocks D-luciferin efflux with an IC₅₀ of 1.5 μM.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

性状

Solid

溶解性数据

In Vitro:

DMSO : 125 mg/mL (424.56 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.3965 mL	16.9825 mL	33.9651 mL
5 mM	0.6793 mL	3.3965 mL	6.7930 mL
10 mM	0.3397 mL	1.6983 mL	3.3965 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式