dFKBP-1|cas:1799711-22-0|西域试剂

dFKBP-1,95.03%

产品编号：Bellancom-103634| CAS NO：1799711-22-0| 分子式：C₅₃H₆₄N₆O₁₄| 分子量：1009.11

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货号	价格	库存与货期
Bellancom-103634	￥5500.00	杭州北京（现货）
Bellancom-103634	￥15000.00	杭州北京（现货）
Bellancom-103634	￥24000.00	杭州北京（现货）

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dFKBP-1

产品介绍

dFKBP-1 是一种基于 PROTAC 的有效的 FKBP12 降解剂。dFKBP-1 包含 FKBP12 配体 SLF (HY-114872)，基于 Thalidomide 的 Cereblon 配体和一个 linker。

生物活性

dFKBP-1 is a potent and PROTAC-based FKBP12 degrader. dFKBP-1 incorporates the ligand SLF (HY-114872) of FKBP12, the Thalidomide based Cereblon ligand and a linker.

体外研究

dFKBP-1 potently decreases FKBP12 abundance in MV4;11 cells, leading to over 80% reduction of FKBP12 at 0.1 μM and 50% reduction at 0.01 μM. As with dBET1, destabilization of FKBP12 by dFKBP-1 is rescued by pre-treatment with Carfilzomib, MLN4924, free SLF or free Thalidomide. Cereblon (CRBN)-dependent degradation is established using previously published isogenic 293FT cell lines which are wild-type (293FT-WT) or deficient (293FT-CRBN^−/−) for CRBN. Treatment of 293FT-WT cells with dFKBP-1 induces potent, dose-dependent degradation of FKBP12, whereas 293FT-CRBN^−/− are unaffected.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

性状

Solid

溶解性数据

In Vitro:

DMSO : 100 mg/mL (99.10 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	0.9910 mL	4.9549 mL	9.9097 mL
5 mM	0.1982 mL	0.9910 mL	1.9819 mL
10 mM	0.0991 mL	0.4955 mL	0.9910 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

参考文献