SRI 6409-94 is an orally active Ro 13-6298 analogue that is teratogenic. SRI 6409-94 serves as a molecular tool to study the effect of the three-dimensional configuration of retinol on teratogenic activity.

SRI 6409-94 causes virgin female outbred syrian golden hamciasters to produce deformed offspring, in a dose-dependent manner.
SRI 6409-94 leads to reductions in mean fetal body weight and in the numbers of ossified skeletal districts, significantly.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

SRI 6409-94 causes virgin female outbred syrian golden hamciasters to produce deformed offspring, in a dose-dependent manner.
SRI 6409-94 leads to reductions in mean fetal body weight and in the numbers of ossified skeletal districts, significantly.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

• . Willhite CC, et al. Structure-activity relationships of retinoids in developmental toxicology. IV. Planar Cisoid conformational restriction. Toxicol Appl Pharmacol. 1990 Apr;103(2):324-44.  [Content Brief]

  . Willhite CC, et al. Structure-affinity relationships of retinoids with embryonic cellular retinoic acid-binding protein. Toxicol Appl Pharmacol. 1992 Jan;112(1):144-53.  [Content Brief]