Aurothioglucose 金硫葡萄糖; Gold thioglucose|cas:12192-57-3|西域试剂

Aurothioglucose 金硫葡萄糖; Gold thioglucose,96.0%

产品编号：Bellancom-A0068| CAS NO：12192-57-3| 分子式：C₆H₁₁AuO₅S| 分子量：392.18

Aurothioglucose (Gold thioglucose) 是众所周知的TrxR1活性位点抑制剂，它能抑制hela细胞中的 TrxR1活性同时对细胞活性无影响。

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-A0068		￥6200.00	杭州北京（现货）

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Aurothioglucose 金硫葡萄糖; Gold thioglucose

产品介绍

Aurothioglucose (Gold thioglucose) 含有单价金离子，是一种有效的 TrxR1 (硫氧还蛋白还原酶 1) 的活性位点抑制剂，其 IC₅₀ 为 65 nM。Aurothioglucose 在体外抑制 NF-κB 的 DNA 结合。Aurothioglucose 具有抗 HIV 和抗风湿的活性。

生物活性

Aurothioglucose (Gold thioglucose), containing monovalent gold ion, is a potent active-site inhibitor of TrxR1 (thioredoxin reductase 1), with an IC₅₀ of 65 nM. Aurothioglucose inhibits the DNA binding of NF-κB in vitro. Aurothioglucose shows anti-HIV and anti-rheumatic activities.

体外研究

Aurothioglucose (0-100 μM, 24-72 h) inhibits TrxR1 activity in HeLa cell cytosol but has no effect on the viability of the cells.
Aurothioglucose (0-30 μM, 6 h) exhibits very low cytotoxicity on cells.
Aurothioglucose (0-20 μM, 24 h) combined with Ebselen (HY-13750) shows a strong synergistic effect, leading to Trx1 (thioredoxin 1) oxidation, reactive oxygen species (ROS) accumulation, and cell death.
Aurothioglucose (0-100 μM, 3-12 days) inhibits p24 levels in OM10.1 and Ach2 cells, and inhibits HIV-1 replication in vitro.
Aurothioglucose (0-25 μM, 12 days) increases the accumulation of metal gold in a dose-dependent manner.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line:	HeLa cells
Concentration:	0, 5, 10, 50, 100 μM
Incubation Time:	24, 48, 72 h
Result:	Inhibited TrxR activity by more than 90% at 100 μM in HeLa cells. Cell viability was unaffected by ATG treatment, even at 100 μM after 72 h.

Western Blot Analysis

Cell Line:	HeLa cells
Concentration:	0, 5, 10, and 100 μM
Incubation Time:	24 h
Result:	Showed no significant oxidation of Trx1 or Trx2 in HeLa cells.

Western Blot Analysis

Cell Line:	OM10.1, Ach2 cells
Concentration:	0, 4, 10, 25 and 100 μM
Incubation Time:	3, 6 or 12 days
Result:	Significantly inhibited p24 levels. After 12 days of incubation, the viability of cells treated with 10, 25 and 100 μM Aurothioglucose had decreased to 60% of the control.

体内研究
(In Vivo)

Aurothioglucose (25 mg/kg, i.p., single) significantly attenuates lung injury and enhances survival in a clinically relevant murine model of ARDS. The protective effects of Aurothioglucose are GSH dependent.
Aurothioglucose (300 mg/kg, i.p., single) induces hypothalamic obesity in mice^[4].

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Adult male C3H/HeN mice (8-12 week, LPS/hyperoxia-exposed mice, inflammation/hyperoxia ARDS model)
Dosage:	25 mg/kg
Administration:	IP, single, at 12 h after intratracheal LPS administration
Result:	Significantly attenuated lung injury, increased lung GCLM expression and GSH levels, and decreased mortality.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Adult male C3H/HeN mice (8-12 week, LPS/hyperoxia-exposed mice, inflammation/hyperoxia ARDS model)
Dosage:	25 mg/kg
Administration:	IP, single, at 12 h after intratracheal LPS administration
Result:	Significantly attenuated lung injury, increased lung GCLM expression and GSH levels, and decreased mortality.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Adult male C3H/HeN mice (8-12 week, LPS/hyperoxia-exposed mice, inflammation/hyperoxia ARDS model)
Dosage:	25 mg/kg
Administration:	IP, single, at 12 h after intratracheal LPS administration
Result:	Significantly attenuated lung injury, increased lung GCLM expression and GSH levels, and decreased mortality.

性状

Solid

溶解性数据

In Vitro:

H₂O : 125 mg/mL (318.73 mM; Need ultrasonic)

DMSO : 6 mg/mL (15.30 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.5498 mL	12.7492 mL	25.4985 mL
5 mM	0.5100 mL	2.5498 mL	5.0997 mL
10 mM	0.2550 mL	1.2749 mL	2.5498 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

参考文献

. Du Y, et al. Glutathione and glutaredoxin act as a backup of human thioredoxin reductase 1 to reduce thioredoxin 1 preventing cell death by aurothioglucose. J Biol Chem. 2012 Nov 2;287(45):38210-9. [Content Brief]

. Traber KE, et al. Anti-rheumatic compound aurothioglucose inhibits tumor necrosis factor-alpha-induced HIV-1 replication in latently infected OM10.1 and Ach2 cells. Int Immunol. 1999 Feb;11(2):143-50. [Content Brief]

. Britt RD Jr, et al. The thioredoxin reductase-1 inhibitor aurothioglucose attenuates lung injury and improves survival in a murine model of acute respiratory distress syndrome. Antioxid Redox Signal. 2014 Jun 10;20(17):2681-91. [Content Brief]

[4]. Naruta E, et al. Hypolipidemic effect of pantothenic acid derivatives in mice with hypothalamic obesity induced by aurothioglucose. Exp Toxicol Pathol. 2001 Oct;53(5):393-8. [Content Brief]

化学品安全说明书(MSDS)

下载MSDS

质检证书(COA)

产品编号(Item Number)

批号(Lot Number)

符号	GHS08
信号词	Danger
危害声明	H317-H334
警示性声明	P261-P280-P284-P304 + P340-P342 + P311
危害码 (欧洲)	Xn: Harmful;
风险声明 (欧洲)	R42/43
安全声明 (欧洲)	S22;S45;S36/S37
危险品运输编码	UN 2811
包装等级	III
危险类别	6.1(b)

1. 物质的识别

产品名：	Aurothioglucose
CAS号：	12192-57-3
制造商/供应商：	西域试剂网站：www.hzbp.cn 邮件：13911702513@139.com

2. 合成/成分数据

产品名：	Aurothioglucose
别名：	Gold thioglucose
分子式：
分子量：	392.18

3. 急救措施

吸入后：	如果吸入，移至空气新鲜处，如果呼吸困难，给输氧，如呼吸停止，给予人工呼吸。
皮肤接触后：	用大量的水冲洗，移除污染的衣服和鞋子。
眼睛接触后：	检查并取下隐形眼镜，并用大量的水冲洗；呼叫医生。
吞食后：	如果吞食，用大量纯净水漱口；呼叫医生。

4. 消防措施

适当的灭火剂：	雾状水，二氧化碳，干粉或泡沫。
防护设备：	穿戴自给式呼吸器和防护服，以防止与皮肤和眼睛接触。

5. 泄漏应急处理

安全防范措施：	封锁泄漏区域；穿戴自给式呼吸器，防护服和厚橡胶手套。
清洁/收集措施：	使用液体粘合原料（硅藻土，通用粘合剂）吸取精细粉末；使用酒精擦洗表面和设备除去污渍；根据第11条处理被污染的材料。

6. 处理和储存

安全处理说明：	避免吸入和接触皮肤，眼睛及衣物；材料可能略微具有刺激性。
储存：	粉末型式 -20°C 3年；4°C 2年溶于溶剂 -80°C 6个月；-20°C 1个月

7. 接触控制和个人防护

呼吸设备：	NIOSH / MSHA认可的呼吸器。
双手保护：	耐化学腐蚀的橡胶手套。
眼睛防护：	化学安全护目镜。

8. 稳定性和反应活性

稳定性：	按照说明存储是稳定的；避免强氧化剂。
热分解/其他要避免的情况：	避免光和热。

9. 毒性资料

急性毒性：	无可用资料。
主要刺激性影响：	无可用资料。
在皮肤上：	无可用资料。
对眼睛：	无可用资料；可能具有刺激性。

10. 生态资料

一般注意事项：

无可用资料。

11. 废弃处置

按照所在国家，省份，县市和地方的法规处置。

12. 运输信息

正确的运输名称：	无
非危险品运输：	这种物质被视为非危险品运输。

13. 法规信息

尚未有针对此产品作出的化学安全性评估。

14. 其他信息

[1]. Watson WH, et al. Thioredoxin reductase-1 knock down does not result in thioredoxin-1 oxidation. Biochem Biophys Res Commun. 2008 Apr 11;368(3):832-6.

[2]. Britt RD Jr, et al. The thioredoxin reductase-1 inhibitor aurothioglucose attenuates lung injury and improves survival in a murine model of acute respiratory distress syndrome. Antioxid Redox Signal. 2014 Jun 10;20(17):2681-91.

Aurothioglucose 金硫葡萄糖; Gold thioglucose,96.0%

Aurothioglucose 金硫葡萄糖; Gold thioglucose

化学品安全说明书(MSDS)

质检证书(COA)

1. 物质的识别

2. 合成/成分数据

3. 急救措施

4. 消防措施

5. 泄漏应急处理

6. 处理和储存

7. 接触控制和个人防护

8. 稳定性和反应活性

9. 毒性资料

10. 生态资料

11. 废弃处置

12. 运输信息

13. 法规信息

14. 其他信息

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