DG172 dihydrochloride|cas:1361504-77-9|西域试剂

DG172 dihydrochloride,99.03%

产品编号：Bellancom-19737A| CAS NO：1361504-77-9| 分子式：C₂₀H₂₂BrCl₂N₃| 分子量：455.22

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-19737A	￥1050.00	杭州北京（现货）
Bellancom-19737A	￥1600.00	杭州北京（现货）
Bellancom-19737A	￥6400.00	杭州北京（现货）
Bellancom-19737A	￥11000.00	杭州北京（现货）

增值税发票√顺丰快递√订货电话：18601927057

DG172 dihydrochloride

产品介绍

DG172 dihydrochloride 是一种选择性的 PPARβ/δ 拮抗剂，IC₅₀ 值为 27 nM。

生物活性

DG172 dihydrochloride is a selective PPARβ/δ antagonist, with an IC₅₀ of 27 nM.

体外研究

DG172 dihydrochloride is a selective PPARβ/δ antagonist, with an IC₅₀ of 27 nM. DG172 enhances transcriptional corepressor recruitment, and down-regulates transcription of the PPARβ/δ target gene Angptl4 in mouse myoblasts (IC₅₀, 9.5 nM). DG172 (1 µM) promotes the differentiation of dendritic cells (DCs) from GM-CSF-induced mouse bone marrow cells (BMCs) and reduces Ly6b⁺/Gr1⁺ granulocytic cells. DG172 has effects on the transcriptome of GM-CSF differentiated BMCs from WT and Ppard null mice, and acts at a specific stage of GM-CSF-induced differentiation. DG172 (0.1, 1.0 µM) dose-dependently promotes proliferation of TM4 cells. DG172 reduces expression of claudin-11 in TM4 cells.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

性状

Solid

溶解性数据

In Vitro:

H₂O : 14.29 mg/mL (31.39 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.1967 mL	10.9837 mL	21.9674 mL
5 mM	0.4393 mL	2.1967 mL	4.3935 mL
10 mM	0.2197 mL	1.0984 mL	2.1967 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

参考文献