B I09|cas:1607803-67-7|西域试剂

B I09,98.82%

产品编号：Bellancom-107400| CAS NO：1607803-67-7| 分子式：C₁₆H₁₇NO₅| 分子量：303.31

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货号	价格	库存与货期
Bellancom-107400	￥1300.00	杭州北京（现货）
Bellancom-107400	￥2000.00	杭州北京（现货）
Bellancom-107400	￥7500.00	杭州北京（现货）
Bellancom-107400	￥13000.00	杭州北京（现货）

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B I09

产品介绍

B I09 是 IRE-1 核糖核酸酶的一个抑制剂，其 IC₅₀ 值为 1230 nM。

生物活性

B I09 is an IRE-1 RNase inhibitor, with an IC₅₀ of 1230 nM.

体外研究

B I09 is an IRE-1 RNase inhibitor, with an IC₅₀ of 1230 nM. Treatment of CLL cells with this inhibitor (B I09) mimick XBP-1 deficiency, including upregulation of IRE-1 expression and compromised BCR signaling. B I09 is highly effective in inhibiting splicing of XBP1 mRNA in human WaC3 cells and the expression of XBP-1s in LPS stimulated B cells.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

B I09 has a halflife of approximately 1.5 hours and reaches its peak concentration of approximately 39 μM in mouse plasma serum 15 minutes after administration. Administration of B I09 to CLL tumor-bearing mice suppress leukemic progression by inducing apoptosis and do not cause systemic toxicity.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : 8.33 mg/mL (27.46 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.2970 mL	16.4848 mL	32.9696 mL
5 mM	0.6594 mL	3.2970 mL	6.5939 mL
10 mM	0.3297 mL	1.6485 mL	3.2970 mL

请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液；该产品在溶液状态不稳定，建议您现用现配，即刻使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: 2.5 mg/mL (8.24 mM); Suspended solution; Need ultrasonic

此方案可获得 2.5 mg/mL (8.24 mM) 的均匀悬浊液，悬浊液可用于口服和腹腔注射。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。
将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明