BDP5290|cas:1817698-21-7|西域试剂

BDP5290,98.79%

产品编号：Bellancom-12437| CAS NO：1817698-21-7| 分子式：C₁₇H₁₈ClN₇O| 分子量：371.82

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货号	价格	库存与货期
Bellancom-12437	￥1500.00	杭州北京（现货）
Bellancom-12437	￥2500.00	杭州北京（现货）
Bellancom-12437	￥5000.00	杭州北京（现货）
Bellancom-12437	￥8000.00	杭州北京（现货）
Bellancom-12437	￥12500.00	杭州北京（现货）

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BDP5290

产品介绍

BDP5290 是 ROCK 和 MRCK 的有效抑制剂，对于 ROCK1，ROCK2，MRCKα 和 MRCKβ 的 IC₅₀ 值分别为 5 nM，50 nM，10 nM 和 100 nM。

生物活性

BDP5290 is a potent inhibitor of both ROCK and MRCK with IC₅₀s of 5 nM, 50 nM, 10 nM and 100 nM for ROCK1, ROCK2, MRCKα and MRCKβ, respectively.

体外研究

The K_i of BDP5290 for MRCKα is 10 nM, which is slightly more than the K_i of 4 nM for MRCKβ. 3 μM BDP5290 completely inhibits myosin II light chain (MLC) phosphorylation induced by MRCKβ, but not by ROCK1 or ROCK2. At higher concentrations, BDP5290 reduces MLC phosphorylation (pMLC) to undetectable levels. BDP5290 reduces MDA-MB-231 invasion at all tested concentrations starting from 0.1 μM, with virtually complete inhibition at 10 μM. After 24 hours in the presence of BDP5290 cell viability is slightly reduced with an EC₅₀ >10 μM. Wound closure is inhibited by >60% at 1 μM BDP5290, a concentration that has no effect on cell viability.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

性状

Solid

溶解性数据

In Vitro:

DMSO : 12.5 mg/mL (33.62 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.6895 mL	13.4474 mL	26.8947 mL
5 mM	0.5379 mL	2.6895 mL	5.3789 mL
10 mM	0.2689 mL	1.3447 mL	2.6895 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式