Super-TDU|cas:1599441-71-0|西域试剂

Super-TDU,96.39%

产品编号：Bellancom-P1727| CAS NO：1599441-71-0| 分子式：C₂₃₇H₃₆₉N₆₅O₇₀S| 分子量：5280.92

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-P1727		￥6000.00	杭州北京（现货）

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Super-TDU

产品介绍

Super-TDU 是一种特异性的 YAP 拮抗剂，可以靶向 YAP-TEAD 相互作用。Super-TDU 可以抑制胃癌小鼠模型的肿瘤生长。

生物活性

Super-TDU is a specific YAP antagonist targeting YAP-TEADs interaction. Super-TDU suppresses tumor growth in gastric cancer mouse model.

体外研究

Super-TDU downregulates expression of YAP-TEADs target genes CTGF, CYR61, and CDX2. Super-TDU inhibits cell viability and colony formation of GC cell lines MGC-803, BGC-823, and HGC27.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Super-TDU (intravenous injection; 50 μg/kg or 500 μg/kg; per day) markedly decreases the sizes, weights of tumors, and YAP target genes in a dose-dependent manner in mice.
Super-TDU (intravenous injection; 250 μg/kg 500 μg/kg) has the t_1/2α of 0.78 hours and 0.82 hours; the C_max of 6.12 ng/mL and 13.3 ng/mL; the CL of 7.41 ml/min/kg and 7.72 ml/min/kg for 250 μg/kg and 500 μg/kg in mice, respectively.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	BALB/cA nu/nu mice
Dosage:	50 μg/kg or 500 μg/kg
Administration:	Intravenous Injection; per day
Result:	Decreased the sizes, weights of tumors, and YAP target genes in a dose-dependent manner.

Animal Model:	BALB/cA nu/nu mice
Dosage:	250 μg/kg or 500 μg/kg (Pharmacokinetic Study)
Administration:	Intravenous Injection
Result:	The t_1/2α is 0.78 hours and 0.82 hours; the C_max is 6.12 ng/mL and 13.3 ng/mL; the CL is7.41 ml/min/kg and 7.72 ml/min/kg for 250 μg/kg and 500 μg/kg in mice, respectively.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	BALB/cA nu/nu mice
Dosage:	50 μg/kg or 500 μg/kg
Administration:	Intravenous Injection; per day
Result:	Decreased the sizes, weights of tumors, and YAP target genes in a dose-dependent manner.

Animal Model:	BALB/cA nu/nu mice
Dosage:	250 μg/kg or 500 μg/kg (Pharmacokinetic Study)
Administration:	Intravenous Injection
Result:	The t_1/2α is 0.78 hours and 0.82 hours; the C_max is 6.12 ng/mL and 13.3 ng/mL; the CL is7.41 ml/min/kg and 7.72 ml/min/kg for 250 μg/kg and 500 μg/kg in mice, respectively.

性状

Solid

溶解性数据

In Vitro:

H₂O : 50 mg/mL (9.47 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	0.1894 mL	0.9468 mL	1.8936 mL
5 mM	0.0379 mL	0.1894 mL	0.3787 mL
10 mM	---	---	---

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶