Dolastatin 10 DLS 10; NSC 376128,98.63%
产品编号：Bellancom-15580| CAS NO：110417-88-4| 分子式：C42H68N6O6S| 分子量：785.09
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Dolastatin 10 DLS 10; NSC 376128
| 产品介绍 | Dolastatin 10 (DLS 10) 是一种有效的抗有丝分裂肽，抑制微管蛋白聚合。 | ||||||||||||||||
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| 生物活性 | Dolastatin 10 (DLS 10) is a potent antimitotic peptide that inhibits tubulin polymerization. | ||||||||||||||||
| 体外研究 |
Dolastatin 10 is a unique pentapeptide that isolated from the sea hare Dolabella auricularia. These in vitro data are quite comparable to those of Dolastatin 10 and Auristatin PE, each of which has GI50 values of 10−5-10−6 μg/mL (10−2-10−3 nM) against a similar minipanel of human cell lines. The antibody-drug conjugate (ADC) comprises the anti-CD30 monoclonal antibody cAC10 conjugated to the cytotoxic agent monomethyl auristatin E (MMAE), a synthetic analog of the tubulin polymerization inhibitor Dolastatin 10. 西域 has not independently confirmed the accuracy of these methods. They are for reference only. | ||||||||||||||||
| 体内研究 | |||||||||||||||||
| 体内研究 | |||||||||||||||||
| 性状 | Solid | ||||||||||||||||
| 溶解性数据 |
In Vitro:
DMSO : ≥ 100 mg/mL (127.37 mM) * "≥" means soluble, but saturation unknown. 配制储备液
*
请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液；该产品在溶液状态不稳定，建议您现用现配，即刻使用。 | ||||||||||||||||
| 运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
| 储存方式 |
Sealed storage, away from moisture
*该产品在溶液状态不稳定，建议您现用现配，即刻使用。 | ||||||||||||||||
| 参考文献 |
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