BOS-172722|cas:1578245-44-9|西域试剂

BOS-172722,99.44%

产品编号：Bellancom-112162| CAS NO：1578245-44-9| 分子式：C₂₄H₃₀N₈O| 分子量：446.55

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货号	价格	库存与货期
Bellancom-112162	￥2200.00	杭州北京（现货）
Bellancom-112162	￥3300.00	杭州北京（现货）
Bellancom-112162	￥6600.00	杭州北京（现货）
Bellancom-112162	￥9900.00	杭州北京（现货）
Bellancom-112162	￥14000.00	杭州北京（现货）

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BOS-172722

产品介绍

BOS-172722 是单极纺锤体 1 (MPS1) 检查点的抑制剂，其对MPS1 (1 mM ATP) 和P-MPS1 的 IC₅₀ 值分别为 11 nM 和 63 nM。BOS-172722 可用于多种乳腺癌的研究。

生物活性

BOS-172722 is an inhibitor of monopolar spindle 1 (MPS1) checkpoint with an IC₅₀ of 11 nM and 63 nM for MPS1 (1 mM ATP) and P-MPS1, respectively. BOS-172722 also has potential for the study of various forms of breast cancer.

体外研究

BOS-172722 is an inhibitor of monopolar spindle 1 (MPS1) checkpoint with an IC₅₀ of 2 nM. BOS-172722 also has potential for the treatment of various forms of breast cancer.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

BOS-172722 shows excellent PK in mouse, rat, and dog.
BOS-172722 (50 mg/kg) results in an increased suppression of MPS1 autophosphorylation at 6 and 24 h.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Dog.
Dosage:	1 mg/kg (iv), 5 mg/kg (po) (Pharmacokinetic Analysis).
Administration:	IV and PO.
Result:	T1/2 = 12 h, Cmax_po = 7770 nmol/L, AUC_po = 147035 h*nmol/L.

体内研究

BOS-172722 shows excellent PK in mouse, rat, and dog.
BOS-172722 (50 mg/kg) results in an increased suppression of MPS1 autophosphorylation at 6 and 24 h.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Dog.
Dosage:	1 mg/kg (iv), 5 mg/kg (po) (Pharmacokinetic Analysis).
Administration:	IV and PO.
Result:	T1/2 = 12 h, Cmax_po = 7770 nmol/L, AUC_po = 147035 h*nmol/L.

性状

Solid

溶解性数据

In Vitro:

1M HCl : 65 mg/mL (145.56 mM; ultrasonic and adjust pH to 2 with HCl)

DMSO : 5 mg/mL (11.20 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.2394 mL	11.1970 mL	22.3939 mL
5 mM	0.4479 mL	2.2394 mL	4.4788 mL
10 mM	0.2239 mL	1.1197 mL	2.2394 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式