Oglufanide 奥谷法奈; H-Glu-Trp-OH; L-Glutamyl-L-tryptophan|cas:38101-59-6|西域试剂

Oglufanide 奥谷法奈; H-Glu-Trp-OH; L-Glutamyl-L-tryptophan,99.49%

产品编号：Bellancom-13718| CAS NO：38101-59-6| 分子式：C₁₆H₁₉N₃O₅| 分子量：333.34

Oglufanide能够抑制VEGF，也能够抑制血管生成。

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-13718	￥1300.00	杭州北京（现货）
Bellancom-13718	￥2100.00	杭州北京（现货）
Bellancom-13718	￥4200.00	杭州北京（现货）
Bellancom-13718	￥6700.00	杭州北京（现货）
Bellancom-13718	￥9800.00	杭州北京（现货）

增值税发票√顺丰快递√订货电话：18601927057

Oglufanide 奥谷法奈; H-Glu-Trp-OH; L-Glutamyl-L-tryptophan

产品介绍

Oglufanide (H-Glu-Trp-OH) 是一种从小牛胸腺中分离出来二肽免疫调节剂，可抑制血管内皮生长因子 (VEGF)。Oglufanide 可以刺激对丙型肝炎病毒 (HCV) 和细胞内细菌感染的免疫反应。Oglufanide 具有抗肿瘤和抗血管生成活性。

生物活性

Oglufanide (H-Glu-Trp-OH) is a dipeptide immunomodulator isolated from calf thymus. Oglufanide inhibits vascular endothelial growth factor (VEGF). Oglufanide can stimulate the immune response to hepatitic C virus (HCV) and intracellular bacterial infections. Oglufanide shows antitumor and anti-angiogenesis activities.

体外研究

Oglufanide (IM862) (1-1000 μg/mL) exhibits dose dependent inhibition of angiogenesis in the chorioallantoic membrane assay with complete inhibition of β-FGF and VEGF-induced angiogenesis.
Oglufanide (L-glu-L-trp) (0-1000 μg/mL; 5 days) has no effect on the viability of either the tumor cell lines or HUVECs^[4].

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Oglufanide (L-glu-L-trp) (1-100 mg/kg/day; s.c.; 10 days) has antitumor activity in immunocompetent and immunodeficient mice^[4].

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BL/6 immune competent mice, Lewis lung carcinoma (LLC) xenograft; Balb/C athymic mice, M21 human melanoma xenograft^[4]
Dosage:	1, 10, 50 and 100 mg/kg/day
Administration:	Subcutaneous injection, 10 days
Result:	Resulted in a dose-dependent inhibition of LLC tumor growth in syngeneic immune competent mice and showed a dose-dependent decrease in tumor volumes of xenografts in Balb/C athymic mice implanted with M21 human melanoma cells.

体内研究

Oglufanide (L-glu-L-trp) (1-100 mg/kg/day; s.c.; 10 days) has antitumor activity in immunocompetent and immunodeficient mice^[4].

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BL/6 immune competent mice, Lewis lung carcinoma (LLC) xenograft; Balb/C athymic mice, M21 human melanoma xenograft^[4]
Dosage:	1, 10, 50 and 100 mg/kg/day
Administration:	Subcutaneous injection, 10 days
Result:	Resulted in a dose-dependent inhibition of LLC tumor growth in syngeneic immune competent mice and showed a dose-dependent decrease in tumor volumes of xenografts in Balb/C athymic mice implanted with M21 human melanoma cells.

性状

Solid

溶解性数据

In Vitro:

DMSO : 15.5 mg/mL (46.50 mM; Need ultrasonic and warming)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.9999 mL	14.9997 mL	29.9994 mL
5 mM	0.6000 mL	2.9999 mL	5.9999 mL
10 mM	0.3000 mL	1.5000 mL	2.9999 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 2.5 mg/mL (7.50 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (7.50 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。
将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (7.50 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (7.50 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。
将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
3.

请依序添加每种溶剂： 10% DMSO 90% corn oil
Solubility: ≥ 2.5 mg/mL (7.50 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (7.50 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在西域网站选购。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

参考文献

. Bayes M, et al. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2005 Jul-Aug;27(6):411-61. [Content Brief]

. Nagendra Kumar Kaushik, et al. Biomedical importance of indoles. Molecules. 2013 Jun 6;18(6):6620-62. [Content Brief]

. Noy A, et al. Angiogenesis inhibitor IM862 is ineffective against AIDS-Kaposi's sarcoma in a phase III trial, but demonstrates sustained, potent effect of highly active antiretroviral therapy: from the AIDS Malignancy Consortium and IM862 Study Team. J Cl [Content Brief]

[4]. Smith DL, et al. Natural killer cell cytolytic activity is necessary for in vivo antitumor activity of the dipeptide L-glutamyl-L-tryptophan. Int J Cancer. 2003 Sep 10;106(4):528-533. [Content Brief]

化学品安全说明书(MSDS)

下载MSDS

质检证书(COA)

产品编号(Item Number)

批号(Lot Number)

上游产品 1
1155-62-0
下游产品 0

Oglufanide 奥谷法奈; H-Glu-Trp-OH; L-Glutamyl-L-tryptophan,99.49%

Oglufanide 奥谷法奈; H-Glu-Trp-OH; L-Glutamyl-L-tryptophan

化学品安全说明书(MSDS)

质检证书(COA)

在线咨询