BAY 2666605|cas:2275774-60-0|西域试剂

BAY 2666605,99.64%

产品编号：Bellancom-145924| CAS NO：2275774-60-0| 分子式：C₁₇H₁₂F₄N₂O₂| 分子量：352.28

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	包装	价格	库存与货期	购买量	操作
Bellancom-145924		￥3700.00	杭州北京（现货）
Bellancom-145924		￥6000.00	杭州北京（现货）

增值税发票√顺丰快递√订货电话：18601927057

BAY 2666605

产品介绍

BAY 2666605 是一种具有口服活性的 PDE3A 和 PDE3B 抑制剂，IC₅₀ 分别为 87 nM 和 50 nM。BAY 2666605 是一种 PDE3A-SLFN12 复合诱导剂 (WO2019025562A1; example 135)。

生物活性

BAY 2666605 is an orally active PDE3A and PDE3B inhibitor with IC₅₀s of 87 nM and 50 nM, respectively. BAY 2666605 is a PDE3A-SLFN12 complex inducer (WO2019025562A1; example 135).

体外研究

BAY 2666605 (example 135) has anticancer effects, potently inhibit brain cancer(especially glioma, more specifically glioblastoma, astrocytoma), breast cancer (especially ductal carcinoma and adenocarcinoma), cervical cancer, AML(especially erythroleucemia), lung cancer(especially NSCLC adenocarcinoma and SCLC), skin cancer(especially melanoma), oesophagus cancer (especially squamous cell carcinoma), ovarian cancer, (especially teratocarcinoma, adenocarcinoma), pancreas cancer and prostatic cancer.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

BAY 2666605 (5 mg/kg; p.o; twice daily) teatment shows anti-tumor efficacy in murine xenotransplantation models of human cancer.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

BAY 2666605 (5 mg/kg; p.o; twice daily) teatment shows anti-tumor efficacy in murine xenotransplantation models of human cancer.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : 250 mg/mL (709.66 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.8387 mL	14.1933 mL	28.3865 mL
5 mM	0.5677 mL	2.8387 mL	5.6773 mL
10 mM	0.2839 mL	1.4193 mL	2.8387 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式