Ningetinib 宁格替尼|cas:1394820-69-9|西域试剂

Ningetinib 宁格替尼,99.79%

产品编号：Bellancom-107145A| CAS NO：1394820-69-9| 分子式：C₃₁H₂₉FN₄O₅| 分子量：556.58

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货号	价格	库存与货期
Bellancom-107145A	￥850.00	杭州北京（现货）
Bellancom-107145A	￥1200.00	杭州北京（现货）
Bellancom-107145A	￥2500.00	杭州北京（现货）
Bellancom-107145A	￥4200.00	杭州北京（现货）
Bellancom-107145A	￥7200.00	杭州北京（现货）

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Ningetinib 宁格替尼

产品介绍

Ningetinib 是一种有效的口服生物可用的小分子酪氨酸激酶抑制剂 (TKI)，对 c-Met，VEGFR2 和 Axl 的 IC₅₀ 值分别为 6.7, 1.9 和 <1.0 nM。

生物活性

Ningetinib is a potent, orally bioavailable small molecule tyrosine kinase inhibitor (TKI) with IC₅₀s of 6.7, 1.9 and <1.0 nM for c-Met, VEGFR2 and Axl, respectively.

体外研究

Ningetinib is a potent, orally bioavailable small molecule tyrosine kinase inhibitor (TKI) with IC₅₀s of 6.7, 1.9 and <1.0 nM for c-Met, VEGFR2 and Axl, respectively. In cell-based functional assays, Ningetinib (CT053PTSA) inhibits HGF and VEGF-stimulated HUVEC proliferation and microvascular angiogenesis in rat aortic rings with IC₅₀ values of 8.6 and 6.3 nM, respectively.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

When single dosed orally (3 mg/kg) to U87MG tumor-bearing nude mice, Ningetinib (CT053PTSA) potently inhibits the phosphorylation of c-Met and its downstream signaling kinases AKT and ERK1/2 for up to 6 hours in tumor tissues. In orthotopic U87MG human glioblastoma xenograft model, Ningetinib prolongs the median survival time (MST) and yields significant increase in life-span value (ILS=32%, p=0.003) at an oral dose of 20 mg/kg/day (dosed 21 days) versus the vehicle-treated group.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : 16.67 mg/mL (29.95 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.7967 mL	8.9834 mL	17.9669 mL
5 mM	0.3593 mL	1.7967 mL	3.5934 mL
10 mM	0.1797 mL	0.8983 mL	1.7967 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式