TMBIM6 antagonist-1|cas:123134-61-2|西域试剂

TMBIM6 antagonist-1,99.80%

产品编号：Bellancom-137175| CAS NO：123134-61-2| 分子式：C₁₅H₁₂N₂O₃| 分子量：268.27

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-137175	￥2500.00	杭州北京（现货）
Bellancom-137175	￥4000.00	杭州北京（现货）
Bellancom-137175	￥11500.00	杭州北京（现货）
Bellancom-137175	￥0.00	杭州北京（现货）

增值税发票√顺丰快递√订货电话：18601927057

TMBIM6 antagonist-1

产品介绍

TMBIM6 antagonist-1 是一个有潜力的 TMBIM6 拮抗剂，抑制 TMBIM6 与 mTORC2 结合，降低 mTORC2 活性，调节TMBIM6 释放 Ca²⁺。

生物活性

TMBIM6 antagonist-1, a potential TMBIM6 antagonist, prevents TMBIM6 binding to mTORC2, decreases mTORC2 activity, and also regulates TMBIM6-leaky Ca²⁺.

体外研究

TMBIM6 antagonist-1 (BIA, 0.5-10 μM, 3 days) significantly and dose-dependently inhibits cell viability in HT1080, MCF7, MDA-MB-2341 and SKBR3 cells, with IC₅₀ values of 1.7 ± 0.1 μM for HT1080, 2.6 ± 0.4 μM for MCF cells, 2.6 ± 0.5 μM for MDA-MB-231 cells, and 2.4 ± 0.4 μM for SKBR3 cells, respectively.
TMBIM6 antagonist-1 (BIA, 10 μM) treatment decreases cell migration in HT1080, MCF7, MDA-MB-231, and SKBR3 cells, not TMBIM6 KO HT1080 cells.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line:	HT1080, MCF7, MDA-MB-2341 and SKBR3 cells.
Concentration:	0.5-10 μM.
Incubation Time:	3 days.
Result:	Inhibited cell viability.

Western Blot Analysis

Cell Line:	WT and TMBIM6 KO HT1080 cells.
Concentration:	0, 2, 5 μM.
Incubation Time:
Result:	Downregulated the protein levels of AKT-pS473.

体内研究
(In Vivo)

TMBIM6 antagonist-1 (1 mg/kg, IP 5 days per week during 25 days) significantly impaires cell-driven tumor growth.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Six- to eight-week BklNbt:BALB/c/nu/nu old mice (HT1080 and MDA-MB-231 cells).
Dosage:	1 mg/kg.
Administration:	IP 5 days per week during 25 days.
Result:	Impaired cell-driven tumor growth.

体内研究

TMBIM6 antagonist-1 (1 mg/kg, IP 5 days per week during 25 days) significantly impaires cell-driven tumor growth.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Six- to eight-week BklNbt:BALB/c/nu/nu old mice (HT1080 and MDA-MB-231 cells).
Dosage:	1 mg/kg.
Administration:	IP 5 days per week during 25 days.
Result:	Impaired cell-driven tumor growth.

体内研究

TMBIM6 antagonist-1 (1 mg/kg, IP 5 days per week during 25 days) significantly impaires cell-driven tumor growth.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Six- to eight-week BklNbt:BALB/c/nu/nu old mice (HT1080 and MDA-MB-231 cells).
Dosage:	1 mg/kg.
Administration:	IP 5 days per week during 25 days.
Result:	Impaired cell-driven tumor growth.

性状

Solid

溶解性数据

In Vitro:

DMSO : 50 mg/mL (186.38 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.7276 mL	18.6379 mL	37.2759 mL
5 mM	0.7455 mL	3.7276 mL	7.4552 mL
10 mM	0.3728 mL	1.8638 mL	3.7276 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式