Risdiplam RG7916; RO7034067|cas:1825352-65-5|西域试剂

Risdiplam RG7916; RO7034067,99.35%

产品编号：Bellancom-109101| CAS NO：1825352-65-5| 分子式：C₂₂H₂₃N₇O| 分子量：401.46

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-109101	￥1500.00	杭州北京（现货）
Bellancom-109101	￥2500.00	杭州北京（现货）
Bellancom-109101	￥4500.00	杭州北京（现货）
Bellancom-109101	￥8500.00	杭州北京（现货）
Bellancom-109101	￥13500.00	杭州北京（现货）

增值税发票√顺丰快递√订货电话：18601927057

Risdiplam RG7916; RO7034067

产品介绍

Risdiplam (RG7916) 是一种运动神经元存活基因 SMN2 的前体 mRNA 剪接修饰剂，可增加 SMN 蛋白水平。

生物活性

Risdiplam (RG7916) is an orally administered, centrally and peripherally distributed SMN2 pre-mRNA splicing modifier that increases survival motor neuron (SMN) protein levels.

体外研究

Risdiplam modulates SMN2 pre-mRNA splicing towards the production of full-length SMN2 mRNA and increases SMN protein levels. Risdiplam is a modifier of SMN2 splicing, leading to an increase in SMN2 full length transcript and thus functional SMN protein. Spinal muscular atrophy (SMA) type I remains the most common genetic disease resulting in death in infancy. Characterized by progressive motor and respiratory muscle weakness, this autosomal recessive neuromuscular disorder is caused by low levels of the survival motor neuron protein (SMN) due to inactivating bi-allelic deletions and other disabling mutations in the survival motor neuron 1 (SMN1) gene.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

性状

Solid

溶解性数据

In Vitro:

DMSO : 1.7 mg/mL (4.23 mM; ultrasonic and warming and heat to 60°C)

Ethanol : < 1 mg/mL (insoluble)

H₂O : < 0.1 mg/mL (insoluble)

*Risdiplam is usually formulated as a suspension.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.4909 mL	12.4545 mL	24.9091 mL
5 mM	---	---	---
10 mM	---	---	---

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式