Pifithrin-α, p-Nitro, Cyclic PFN-α|cas:60477-38-5|西域试剂

Pifithrin-α, p-Nitro, Cyclic PFN-α,98.0%

产品编号：Bellancom-123076| CAS NO：60477-38-5| 分子式：C₁₅H₁₃N₃O₂S| 分子量：299.35

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-123076	￥1000.00	杭州北京（现货）
Bellancom-123076	￥1600.00	杭州北京（现货）
Bellancom-123076	￥3200.00	杭州北京（现货）
Bellancom-123076	￥5200.00	杭州北京（现货）
Bellancom-123076	￥8600.00	杭州北京（现货）

增值税发票√顺丰快递√订货电话：18601927057

Pifithrin-α, p-Nitro, Cyclic PFN-α

产品介绍

Pifithrin-α, p-Nitro, Cyclic (PFN-α)，是细胞通透性的 p53 抑制剂。Pifithrin-α, p-Nitro, Cyclic 对暴露于 Etoposide 的皮层神经元的保护作用比 Pifithrin-α 强一个数量级 (ED₅₀=30 nM)。Pifithrin-α, p-Nitro, Cyclic 也作为 p53 转录后活性抑制剂。Pifithrin-α, p-Nitro, Cyclic 不阻止 p53 上的 S15 残基磷酸化。

生物活性

Pifithrin-α, p-Nitro, Cyclic (PFN-α) is cell-permeable and active-form p53 inhibitor. Pifithrin-α, p-Nitro, Cyclic is one order magnitude more active than Pifithrin-α in protecting cortical neurons exposed to Etoposide (ED₅₀=30 nM). Pifithrin-α, p-Nitro, Cyclic behaves as a p53 posttranscriptional activity inhibitor. Pifithrin-α, p-Nitro, Cyclic do not prevent p53 phosphorylation on the S15 residue.

体外研究

Pifithrin-α, p-Nitro, Cyclic (PFN-α) efficiently blocks p53-triggered cell death and p21/WAF1 expression in cortical neurons exposed to etoposide at concentrations one order magnitude lower than that in PFT-α.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Intraocular injection of pifithrin-α slightly increases survival of retinal ganglion cell (RGC) at the concentration of 6 μM but not at 0.06 μM. Pifithrin-α, p-Nitro, Cyclic (PFN-α) is not effective in vivo, even at 6 μM.
Pifithrin-α, p-Nitro, Cyclic shows the half-life (t_1/2) of 6 hours (when incubated in biological conditions).

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMF : 12.5 mg/mL (41.76 mM; Need ultrasonic)

DMSO : 5 mg/mL (16.70 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.3406 mL	16.7029 mL	33.4057 mL
5 mM	0.6681 mL	3.3406 mL	6.6811 mL
10 mM	0.3341 mL	1.6703 mL	3.3406 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

参考文献