SKF 38393 hydrochloride (±-SKF-38393 hydrochloride; SKF-38393A)|cas:62717-42-4|西域试剂

SKF 38393 hydrochloride (±-SKF-38393 hydrochloride; SKF-38393A),99.44%

产品编号：Bellancom-12520A| CAS NO：62717-42-4| 分子式：C₁₆H₁₈ClNO₂| 分子量：291.77

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货号	价格	库存与货期
Bellancom-12520A	￥713.00	杭州北京（现货）
Bellancom-12520A	￥800.00	杭州北京（现货）
Bellancom-12520A	￥1200.00	杭州北京（现货）
Bellancom-12520A	￥3200.00	杭州北京（现货）

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SKF 38393 hydrochloride (±-SKF-38393 hydrochloride; SKF-38393A)

产品介绍

SKF 38393 hydrochloride 是一种多巴胺 D1 受体 (dopamine D1 receptor) 的选择性激动剂, IC₅₀ 值为 110 nM。

生物活性

SKF 38393 hydrochloride is a selective agonist of the dopamine D1 receptor (D1DR) with an IC₅₀ of 110 nM.

体外研究

SKF-38393 hydrochloride induces a similar change in cytomorphology and increases the levels of media cAMP.
SKF-38393 hydrochloride (10 μmol/L; 1 hour) induces increased threonine-phosphorylation of DA- and cAMP-regulated phosphoprotein of Mr 32 kD (DARPP-32) in cultured GC cells.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis.

Cell Line:	GC cells
Concentration:	10 μmol/L
Incubation Time:	1 hour
Result:	Induced increased threonine-phosphorylation of DA- and cAMP-regulated phosphoprotein of Mr 32 kD (DARPP-32) in cultured GC cells.

体内研究
(In Vivo)

SKF-38393 hydrochloride (10 mg/kg; i.p.) blocks the 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) -induced depletion of glutathione.
SKF-38393 hydrochloride attenuates MPTP-induced depletion of dopamine.
SKF-38393 hydrochloride enhances the activity of superoxide dismutase and hence mimics the action of Selegiline.
SKF-38393 hydrochloride enhances the frequency but not the amplitude of tetrodotoxin-resistant excitatory postsynaptic currents which argues for a presynaptic locus of D1 action^[4].

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Balb/c mice ( 20-25 g).
Dosage:	5 mg/kg, 10 mg/kg
Administration:	Intraperitoneal injection
Result:	Blocked the MPTP-induced depletion of glutathione and attenuated MPTP-induced depletion of dopamine.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Balb/c mice ( 20-25 g).
Dosage:	5 mg/kg, 10 mg/kg
Administration:	Intraperitoneal injection
Result:	Blocked the MPTP-induced depletion of glutathione and attenuated MPTP-induced depletion of dopamine.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Balb/c mice ( 20-25 g).
Dosage:	5 mg/kg, 10 mg/kg
Administration:	Intraperitoneal injection
Result:	Blocked the MPTP-induced depletion of glutathione and attenuated MPTP-induced depletion of dopamine.

性状

Solid

溶解性数据

In Vitro:

DMSO : ≥ 34 mg/mL (116.53 mM)

H₂O : 10 mg/mL (34.27 mM; Need ultrasonic)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.4274 mL	17.1368 mL	34.2736 mL
5 mM	0.6855 mL	3.4274 mL	6.8547 mL
10 mM	0.3427 mL	1.7137 mL	3.4274 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.08 mg/mL (7.13 mM); Clear solution

此方案可获得 ≥ 2.08 mg/mL (7.13 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。
将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明