PKR-IN-C16|cas:608512-97-6|西域试剂

PKR-IN-C16,99.78%

产品编号：Bellancom-13977A| CAS NO：608512-97-6| 分子式：C₁₃H₈N₄OS| 分子量：268.29

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货号	价格	库存与货期
Bellancom-13977A	￥1000.00	杭州北京（现货）
Bellancom-13977A	￥1700.00	杭州北京（现货）
Bellancom-13977A	￥3500.00	杭州北京（现货）
Bellancom-13977A	￥5500.00	杭州北京（现货）
Bellancom-13977A	￥9500.00	杭州北京（现货）

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PKR-IN-C16

产品介绍

PKR-IN-C16 (Compound C16) 是一种特异的双链 RNA 依赖蛋白激酶 (PKR) 抑制剂。PKR-IN-C16 具有良好的神经保护作用，可挽救急性脑损伤。

生物活性

PKR-IN-C16 (Compound C16) is a specific double-stranded RNA-dependent protein kinase (PKR) inhibitor. PKR-IN-C16 shows promising neuroprotective properties and can rescue acute brain lesions.

体外研究

PKR-IN-C16 (Compound C16) is able to unlock the translation blockade induced by PKR in primary neuronal cultures.
PKR-IN-C16 (0.1 or 0.3 μM; 24 h) shows protective effect against the neuronal cell death induced by endoplasmic reticulum stress in SH-SY5Y cells.
PKR-IN-C16 (1-1000 nM; 4 h) prevents not only PKR-phosphorylation but also the activation of caspase-3 induced by Amyloid β in SH-SY5Y cells.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis

Cell Line:	Human SH-SY5Y cells
Concentration:	1, 10, 20, 200, 1000 nM
Incubation Time:	4 h
Result:	Markedly reduces the level of phosphorylated PKR in the cells exposed to 20 μM Amyloid β.

体内研究
(In Vivo)

PKR-IN-C16 (Compound C16) (60 or 600 μg/kg; i.p.; 3 times) prevents not only the PKR-induced neuronal loss but also the inflammatory response in the Quinolinic acid (QA) (HY-100807) induced acute excitotoxic rat model

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Normotensive male Wistar rats, excitotoxic neuroinflammatory model, inflammation was induced by unilateral striatal injection of quinolinic acid (QA)
Dosage:	60 or 600 μg/kg
Administration:	Intraperitoneal injection; 24 h, 2 h before QA injection and 24 h post-QA injection
Result:	Reduced expression of the active catalytic domain of the PKR, prevented increase of IL-1β levels on the contralateral side (97% inhibition) at 600 μg/kg. Decreased by 47% the neuronal loss and by 37% the number of positive cleaved caspase-3 neurons induced by QA injection at 600 μg/kg.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Normotensive male Wistar rats, excitotoxic neuroinflammatory model, inflammation was induced by unilateral striatal injection of quinolinic acid (QA)
Dosage:	60 or 600 μg/kg
Administration:	Intraperitoneal injection; 24 h, 2 h before QA injection and 24 h post-QA injection
Result:	Reduced expression of the active catalytic domain of the PKR, prevented increase of IL-1β levels on the contralateral side (97% inhibition) at 600 μg/kg. Decreased by 47% the neuronal loss and by 37% the number of positive cleaved caspase-3 neurons induced by QA injection at 600 μg/kg.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Normotensive male Wistar rats, excitotoxic neuroinflammatory model, inflammation was induced by unilateral striatal injection of quinolinic acid (QA)
Dosage:	60 or 600 μg/kg
Administration:	Intraperitoneal injection; 24 h, 2 h before QA injection and 24 h post-QA injection
Result:	Reduced expression of the active catalytic domain of the PKR, prevented increase of IL-1β levels on the contralateral side (97% inhibition) at 600 μg/kg. Decreased by 47% the neuronal loss and by 37% the number of positive cleaved caspase-3 neurons induced by QA injection at 600 μg/kg.

性状

Solid

溶解性数据

In Vitro:

DMSO : 7.35 mg/mL (27.40 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.7273 mL	18.6365 mL	37.2731 mL
5 mM	0.7455 mL	3.7273 mL	7.4546 mL
10 mM	0.3727 mL	1.8637 mL	3.7273 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式