Manzamine A hydrochloride Keramamine A hydrochloride|cas:104264-80-4|西域试剂

Manzamine A hydrochloride Keramamine A hydrochloride,99.29%

产品编号：Bellancom-117025A| CAS NO：104264-80-4| 分子式：C₃₆H₄₅ClN₄O| 分子量：585.22

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-117025A		￥2500.00	杭州北京（现货）
Bellancom-117025A		￥8000.00	杭州北京（现货）

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Manzamine A hydrochloride Keramamine A hydrochloride

产品介绍

Manzamine A hydrochloride 是一种具有口服活性的 β-carboline 生物碱，抑制 GSK-3β 和 CDK-5 的 IC₅₀ 值为 10.2 μM 和 1.5 μM。Manzamine A hydrochloride 靶向胰腺癌细胞的 vacuolar ATPases 并抑制自噬 (autophagy)。Manzamine A hydrochloride 具有抗疟和抗癌活性。Manzamine A hydrochloride 对 HSV-1 具有较强的活性。

生物活性

Manzamine A hydrochloride, an orally active beta-carboline alkaloid, inhibits specifically GSK-3β and CDK-5 with IC₅₀s of 10.2 μM and 1.5 μM, respectively. Manzamine A hydrochloride targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells. Manzamine A hydrochloride has antimalarial and anticancer activities. Manzamine A hydrochloride also shows potent activity against HSV-1^[4].

体外研究

Manzamine A (5-50 µM, 18 h) hydrochloride decreases tau phosphorylation, measured with ELISA.
Manzamine A (10 µM) hydrochloride inhibits yeast S. cerevisiae growth by 30%.
Manzamine A hydrochloride displays a few enlarged vacuoles in yeast.
Manzamine A (2.5-10 µM, 24 h) hydrochloride increases acidity in pancreatic cancer cells and non-malignant Vero cells.
Manzamine A (1 µM, 24 h) hydrochloride inhibits HSV-1 infection in SIRC cells^[4].
Manzamine A hydrochloride shows antimalarial activity with an IC₅₀ of 8.0 nM (D6 clone) and 11 nM (W2 clone)^[5].

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[4]

Cell Line:	SIRC cell
Concentration:	0.1, 0.5, 1, 2, 3, 5, and 10 µM
Incubation Time:	72 h
Result:	Inhibited SIRC cell viability with an IC₅₀ of 5.6 µM.

体内研究
(In Vivo)

Manzamine A (50 and 100 mol/kg, p.o. or i.p.) hydrochloride inhibits the growth of the rodent malaria parasite Plasmodium berghei in infected mice^[6].
Manzamine A (8 mg/kg, i.p., daily for 8 consecutive days) hydrochloride prolongs the survival of SW mice to 20 days^[7].

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Plasmodium berghei in infected mice^[6]
Dosage:	50 or 100 mol/kg
Administration:	Intraperitoneal injection (i.p.) or oral administration (p.o.)
Result:	Inhibited the growth of the rodent malaria parasite Plasmodium berghei. Prolonged the survival of highly parasitaemic mice.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Plasmodium berghei in infected mice^[6]
Dosage:	50 or 100 mol/kg
Administration:	Intraperitoneal injection (i.p.) or oral administration (p.o.)
Result:	Inhibited the growth of the rodent malaria parasite Plasmodium berghei. Prolonged the survival of highly parasitaemic mice.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Plasmodium berghei in infected mice^[6]
Dosage:	50 or 100 mol/kg
Administration:	Intraperitoneal injection (i.p.) or oral administration (p.o.)
Result:	Inhibited the growth of the rodent malaria parasite Plasmodium berghei. Prolonged the survival of highly parasitaemic mice.

性状

Solid

溶解性数据

In Vitro:

DMSO : 5.88 mg/mL (10.05 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.7088 mL	8.5438 mL	17.0876 mL
5 mM	0.3418 mL	1.7088 mL	3.4175 mL
10 mM	0.1709 mL	0.8544 mL	1.7088 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

参考文献