NV-5138|cas:2095886-80-7|西域试剂

NV-5138,98.0%

产品编号：Bellancom-114384| CAS NO：2095886-80-7| 分子式：C₇H₁₃F₂NO₂| 分子量：181.18

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货号	价格	库存与货期
Bellancom-114384	￥2500.00	杭州北京（现货）
Bellancom-114384	￥4000.00	杭州北京（现货）
Bellancom-114384	￥8500.00	杭州北京（现货）
Bellancom-114384	￥13500.00	杭州北京（现货）
Bellancom-114384	￥19500.00	杭州北京（现货）

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NV-5138

产品介绍

NV-5138 是一种亮氨酸类似物，是首个具有选择性的、口服活性的脑内的 mTORC1 的激动剂，与 Sestrin2 结合。NV-5138 可用于抗抑郁的生物研究。

生物活性

NV-5138, a leucine analog, is the first selective and orally active brain mTORC1 activator, binding to Sestrin2. NV-5138 is used for antidepressant studies.

体外研究

体内研究

NV-5138 is found to be essentially 100% orally bioavailable with an elimination half-life in plasma of ~ 3 h determined following intravenous and oral dosing in rats.
NV-5138 (160 mg/kg, po, single dose) rapidly increases levels of phospho-mTOR as well as the downstream targets, phospho-p70S6K1, and phosphor-4EB-P1, in synaptosomal preparations of PFC.
NV-5138 (80 mg/kg, po, daily for a total of 7 days) also produces antidepressant effects.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Sprague-Dawley rats weighing 250-260 g.
Dosage:	40, 80, 160 mg/kg.
Administration:	PO, single dose (160 mg/kg) or daily for a total of 7 days (40, 80 mg/kg).
Result:	Produced antidepressant effects.

Animal Model:	Male Sprague–Dawley (SD) rats weighed 250-400 g.
Dosage:	1 mg/kg, 5 mg/kg (Pharmacokinetic Design).
Administration:	I.V at 1 mg/kg and PO at 5 mg/kg.
Result:	Essentially 100% orally bioavailable with an elimination half-life in plasma of ~ 3 h.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Sprague-Dawley rats weighing 250-260 g.
Dosage:	40, 80, 160 mg/kg.
Administration:	PO, single dose (160 mg/kg) or daily for a total of 7 days (40, 80 mg/kg).
Result:	Produced antidepressant effects.

Animal Model:	Male Sprague–Dawley (SD) rats weighed 250-400 g.
Dosage:	1 mg/kg, 5 mg/kg (Pharmacokinetic Design).
Administration:	I.V at 1 mg/kg and PO at 5 mg/kg.
Result:	Essentially 100% orally bioavailable with an elimination half-life in plasma of ~ 3 h.

性状

Solid

溶解性数据

In Vitro:

DMSO : 25 mg/mL (137.98 mM; ultrasonic and adjust pH to 2 with HCl)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	5.5194 mL	27.5969 mL	55.1937 mL
5 mM	1.1039 mL	5.5194 mL	11.0387 mL
10 mM	0.5519 mL	2.7597 mL	5.5194 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式