SAR7334|cas:1333210-07-3|西域试剂

SAR7334,99.88%

产品编号：Bellancom-15699| CAS NO：1333210-07-3| 分子式：C₂₁H₂₂ClN₃O| 分子量：367.87

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货号	价格	库存与货期
Bellancom-15699	￥2300.00	杭州北京（现货）
Bellancom-15699	￥4000.00	杭州北京（现货）
Bellancom-15699	￥7200.00	杭州北京（现货）
Bellancom-15699	￥9000.00	杭州北京（现货）

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SAR7334

产品介绍

SAR7334 是一种有效的 TRPC6 特异性抑制剂，能够抑制 TRPC6 电流，IC₅₀ 值为 7.9 nM。

生物活性

SAR7334 is a potent and specific TRPC6 inhibitor, inhibiting TRPC6 currents with IC₅₀ of 7.9 nM.

体外研究

SAR7334 inhibits TRPC6, TRPC3 and TRPC7-mediated Ca²⁺ influx into cells with IC₅₀s of 9.5, 282 and 226 nM, whereas TRPC4 and TRPC5-mediated Ca²⁺ entry is not affected. SAR7334 (1 μM) results in a major block of the Ang II-evoked calcium influx in the podocytes. SAR7334 (1 μM) has negligible effect on SOCE. SAR7334 dose-dependently reduces TRPC6 currents with an IC₅₀ of 7.9 nM. SAR7334 (100 nM) substantially reduces TRPC6 currents.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

SAR7334 (10 mg/kg, p.o.) suppresses TRPC6-dependent acute HPV in isolated perfused lungs from mice. SAR7334 demonstrates that it is suitable for chronic oral administration. In an initial short-term study, SAR7334 does not change mean arterial pressure in spontaneously hypertensive rats (SHR).

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : ≥ 370 mg/mL (1005.79 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.7184 mL	13.5918 mL	27.1835 mL
5 mM	0.5437 mL	2.7184 mL	5.4367 mL
10 mM	0.2718 mL	1.3592 mL	2.7184 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式