P7C3|cas:301353-96-8|西域试剂

P7C3,99.97%

产品编号：Bellancom-15976| CAS NO：301353-96-8| 分子式：C₂₁H₁₈Br₂N₂O| 分子量：474.19

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-15976	￥660.00	杭州北京（现货）
Bellancom-15976	￥900.00	杭州北京（现货）
Bellancom-15976	￥3000.00	杭州北京（现货）
Bellancom-15976	￥5500.00	杭州北京（现货）

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P7C3

产品介绍

P7C3 是一种具有口服活性的，可透过血脑屏障的 aminopropyl carbazole 类化合物，具有神经保护作用。P7C3 可用于神经退行性疾病，包括帕金森病的研究。

生物活性

P7C3 is an orally bioavailable and blood-brain barrier penetrant aminopropyl carbazole, with neuroprotective effects. P7C3 can be used for the research of neurodegenerative diseases, including Parkinson's disease.

体外研究

P7C3 inhibits LPS-induced production of pro-inflammatory factors in BV2 cells.
P7C3 markedly reduces the protein levels of iNOS and COX-2 in a dose-dependent manner without affecting the cell viability in the LPS (100 ng/mL)-stimulated BV2 cells.
P7C3 inhibits LPS-induced nuclear translocation of NF-κB p65 subunit in BV2 cells.
P7C3 suppresses LPS-induced degradation of inhibitory κB alpha (IκBα) by inhibiting IκB kinase (IKK) activation.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis

Cell Line:	BV2 cells
Concentration:	0.1 μM, 1 μM, 10 μM
Incubation Time:	2 hours
Result:	Reduced the protein levels of iNOS, COX-2.

体内研究
(In Vivo)

P7C3 (20 mg/kg/d; i.p.; twice daily; for 21 days ) inhibits microglial activation and microglia-mediated dopaminergic (DA) neuronal loss in vivo.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	6-8 weeks male C57BL/6 mice (25-30 g)
Dosage:	20 mg/kg/d
Administration:	Intraperitoneal injection, twice daily, for 21 days
Result:	Strikingly decreased the expressions of (a microglia marker) and GFAP (an astrocyte marker) LPS-induced in the substantia nigra pars compacta (SNpc).

体内研究

P7C3 (20 mg/kg/d; i.p.; twice daily; for 21 days ) inhibits microglial activation and microglia-mediated dopaminergic (DA) neuronal loss in vivo.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	6-8 weeks male C57BL/6 mice (25-30 g)
Dosage:	20 mg/kg/d
Administration:	Intraperitoneal injection, twice daily, for 21 days
Result:	Strikingly decreased the expressions of (a microglia marker) and GFAP (an astrocyte marker) LPS-induced in the substantia nigra pars compacta (SNpc).

体内研究

P7C3 (20 mg/kg/d; i.p.; twice daily; for 21 days ) inhibits microglial activation and microglia-mediated dopaminergic (DA) neuronal loss in vivo.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	6-8 weeks male C57BL/6 mice (25-30 g)
Dosage:	20 mg/kg/d
Administration:	Intraperitoneal injection, twice daily, for 21 days
Result:	Strikingly decreased the expressions of (a microglia marker) and GFAP (an astrocyte marker) LPS-induced in the substantia nigra pars compacta (SNpc).

性状

Solid

溶解性数据

In Vitro:

DMSO : ≥ 33 mg/mL (69.59 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.1089 mL	10.5443 mL	21.0886 mL
5 mM	0.4218 mL	2.1089 mL	4.2177 mL
10 mM	0.2109 mL	1.0544 mL	2.1089 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 2.08 mg/mL (4.39 mM); Clear solution

此方案可获得 ≥ 2.08 mg/mL (4.39 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。
将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂： 10% DMSO 90% corn oil
Solubility: ≥ 2.08 mg/mL (4.39 mM); Clear solution

此方案可获得 ≥ 2.08 mg/mL (4.39 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。
以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。