LM11A-31 dihydrochloride|cas:1243259-19-9|西域试剂

LM11A-31 dihydrochloride,98.0%

产品编号：Bellancom-110155| CAS NO：1243259-19-9| 分子式：C₁₂H₂₇Cl₂N₃O₂| 分子量：316.27

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-110155	￥1100.00	杭州北京（现货）
Bellancom-110155	￥1500.00	杭州北京（现货）
Bellancom-110155	￥3150.00	杭州北京（现货）
Bellancom-110155	￥4650.00	杭州北京（现货）
Bellancom-110155	￥8500.00	杭州北京（现货）

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LM11A-31 dihydrochloride

产品介绍

LM11A-31 dihydrochloride 是一种 p75^NTR (神经营养蛋白受体 p75) 非肽调节剂，是口服有效的 proNGF 拮抗剂。LM11A-31 dihydrochloride 是一种具有高血脑屏障通透性的氨基酸衍生物，能阻断 p75 介导的细胞死亡。LM11A-31 dihydrochloride 可以逆转中晚期的阿尔茨海默氏病小鼠模型中的胆碱能神经突营养不良。

生物活性

LM11A-31 dihydrochloride, a non-peptide p75^NTR (neurotrophin receptor p75) modulator, is an orally active and potent proNGF (nerve growth factor) antagonist. LM11A-31 dihydrochloride is an amino acid derivative with high blood-brain barrier permeability and blocks p75-mediated cell death. M11A-31 dihydrochloride reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models with mid- to late-stage disease progression.

体外研究

体内研究

LM11A-31 (oral gavage; 50 mg kg/day for 4 weeks) significantly mitigates proNGF accumulation and preserves BRB integrity.
LM11A-31 (orally; 50 or 75 mg/kg) administered for 3 months starting at 6-8 months of age prevents and/or reverses atrophy of basal forebrain cholinergic neurites and cortical dystrophic neurites in mid-stage male APPL/S mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male C57BL/6 J mice
Dosage:	50 mg kg/day
Administration:	Oral gavage; for 4 weeks
Result:	Mitigated proNGF accumulation and preserved BRB integrity.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male C57BL/6 J mice
Dosage:	50 mg kg/day
Administration:	Oral gavage; for 4 weeks
Result:	Mitigated proNGF accumulation and preserved BRB integrity.

性状

Solid

溶解性数据

In Vitro:

H₂O : 100 mg/mL (316.19 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.1619 mL	15.8093 mL	31.6186 mL
5 mM	0.6324 mL	3.1619 mL	6.3237 mL
10 mM	0.3162 mL	1.5809 mL	3.1619 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶