Vigabatrin 氨己烯酸; γ-Vinyl-GABA|cas:68506-86-5|西域试剂

Vigabatrin 氨己烯酸; γ-Vinyl-GABA,98.0%

产品编号：Bellancom-15399| CAS NO：68506-86-5| 分子式：C₆H₁₁NO₂| 分子量：129.16

Vigabatrin盐酸盐(γ-Vinyl-GABA; Sabril)是GABA的结构类似物，能不可逆地抑制GABA氨基转移酶对GABA的分解代谢。

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	包装	价格	库存与货期	购买量	操作
Bellancom-15399		￥800.00	杭州北京（现货）
Bellancom-15399		￥3200.00	杭州北京（现货）

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Vigabatrin 氨己烯酸; γ-Vinyl-GABA

产品介绍

Vigabatrin (γ-Vinyl-GABA)，一种抑制性神经递质 GABA 乙烯基衍生物，是一种具有口服活性且不可逆的 GABA 转氨酶 (GABA transaminase) 抑制剂。 Vigabatrin 是一种抗癫痫剂，通过抑制 GABA transaminase 对 GABA 的分解代谢来增加脑中 GABA 的水平。

生物活性

Vigabatrin (γ-Vinyl-GABA), an inhibitory neurotransmitter GABA vinyl-derivative, is an orally active and irreversible GABA transaminase inhibitor. Vigabatrin is an antiepileptic agent, which acts by increasing GABA levels in the brain by inhibiting the catabolism of GABA by GABA transaminase.

体外研究

A significant increase in seizure threshold is observed following systemic (i.p.) administration of high (600 or 1200 mg/kg) doses of Vigabatrin. Bilateral microinjection of Vigabatrin (10 μg) into either the anterior or posterior substantia nigra pars reticulata (SNr) also increased seizure threshold, but less markedly than systemic treatment. Focal delivery into the subthalamic nucleus (STN) increased seizure threshold more markedly than either intranigral or systemic administration of Vigabatrin.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Vigabatrin inhibits the uptake of taurine in Caco-2 and MDCK cells to 34% and 53%, respectively, at a concentration of 30 mM. In Caco-2 cells the uptake of Vigabatrin under neutral pH conditions is concentration-dependent and saturable with a Km-value of 27 mM. Vigabatrin is able to inhibit the uptake of taurine in intestinal and renal cell culture models.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

H₂O : 50 mg/mL (387.12 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	7.7423 mL	38.7117 mL	77.4233 mL
5 mM	1.5485 mL	7.7423 mL	15.4847 mL
10 mM	0.7742 mL	3.8712 mL	7.7423 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： PBS
Solubility: 100 mg/mL (774.23 mM); Clear solution; Need ultrasonic

*以上所有助溶剂都可在西域网站选购。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

参考文献

. Broeer, et al. Vigabatrin for focal drug delivery in epilepsy: Bilateral microinfusion into the subthalamic nucleus is more effective than intranigral or systemic administration in a rat seizure model. Neurobiology of Disease (2012), 46(2), 362-376. [Content Brief]

. Jakob Plum, et al. The anti-epileptic drug substance vigabatrin inhibits taurine transport in intestinal and renal cell culture models. Int J Pharm. 2014 Oct 1;473(1-2):395-7. [Content Brief]

. Gaily, Eija Vigabatrin monotherapy for infantile spasms. Expert Review of Neurotherapeutics (2012), 12(3), 275-286. [Content Brief]

化学品安全说明书(MSDS)

下载MSDS

质检证书(COA)

产品编号(Item Number)

批号(Lot Number)

个人防护装备	dust mask type N95 (US);Eyeshields;Gloves
危险品运输编码	NONH for all modes of transport
RTECS号	MP7745000

Vigabatrin 氨己烯酸; γ-Vinyl-GABA,98.0%

Vigabatrin 氨己烯酸; γ-Vinyl-GABA

化学品安全说明书(MSDS)

质检证书(COA)

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