BAY 73-6691 (R-BAY 73-6691)|cas:794568-92-6|西域试剂

BAY 73-6691 (R-BAY 73-6691),99.81%

产品编号：Bellancom-104028| CAS NO：794568-92-6| 分子式：C₁₅H₁₂ClF₃N₄O| 分子量：356.73

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-104028	￥1500.00	杭州北京（现货）
Bellancom-104028	￥2500.00	杭州北京（现货）
Bellancom-104028	￥5300.00	杭州北京（现货）
Bellancom-104028	￥9100.00	杭州北京（现货）
Bellancom-104028	￥15000.00	杭州北京（现货）

增值税发票√顺丰快递√订货电话：18601927057

BAY 73-6691 (R-BAY 73-6691)

产品介绍

BAY 73-6691 ((R)-BAY 73-6691) 是一种有效的，可透过血脑屏障的选择性 PDE9A 抑制剂。

生物活性

BAY 73-6691 ((R)-BAY 73-6691) is a potent, brain penetrant, and selective PDE9A inhibitor.

体外研究

The BAY 73-6691 dose-dependently alleviates cell viability loss due to Aβ_25-35 treatment. It is found that when SH-SY5Y cells are cultured by Aβ_25-35, a high degree of cell apoptosis is observed, while additional stimulation with BAY 73-6691 causes attenuation of cell apoptosis. BAY 73-6691 dose-dependently attenuates oxidative stress induced by Aβ_25-35, and BAY 73-6691 at 200 μg/mL almost neutralizes Aβ_25-35-induced oxidative damage. The BAY 73-6691 attenuates Aβ_25-35-induced increase of apoptosis cells.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

BAY 73-6691 dose-dependently improves the acquisition performance in the Aβ_25-35-injected mice on days 7 to 10 (day 7, F_(5,54)=65.153; day 8, F_(5,54)=62.340; day 9, F_(5,54)=37.529; day 10, F_(5,54)=38.624; P<0.001). BAY 73-6691 at 3 mg/kg can almost completely abolish the prolongation of escape-latency on days 9 to 10. BAY 73-6691 dose-dependently elevates the Aβ_25-35-induced decrease of the dwell time on the 10th day post Aβ_25-35 injection (day 10, F_(5,54)=27.360, P<0.001). Results reveal that the Aβ_25-35 injection and BAY 73-6691 treatment cause no influence on the swimming speed. Treatment with BAY 73-6691 does not cause detectable alteration of spatial memory in sham mice. BAY 73-6691 alleviates Aβ_25-35-induced abnormalities of the above indices. The BAY 73-6691 causes no influence on the four indices mentioned above in sham mice. The BAY 73-6691 has no significant effect on the apoptosis of hippocampal neurons in sham mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : 160 mg/mL (448.52 mM; Need ultrasonic and warming)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.8032 mL	14.0162 mL	28.0324 mL
5 mM	0.5606 mL	2.8032 mL	5.6065 mL
10 mM	0.2803 mL	1.4016 mL	2.8032 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: 2.5 mg/mL (7.01 mM); Suspended solution; Need ultrasonic

此方案可获得 2.5 mg/mL (7.01 mM) 的均匀悬浊液，悬浊液可用于口服和腹腔注射。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。
将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
2.

请依序添加每种溶剂： 10% DMSO 90% corn oil
Solubility: ≥ 2.5 mg/mL (7.01 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (7.01 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。