LP-922761|cas:1454808-95-7|西域试剂

LP-922761,98.21%

产品编号：Bellancom-120179| CAS NO：1454808-95-7| 分子式：C₂₁H₂₆N₆O₃| 分子量：410.47

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货号	价格	库存与货期
Bellancom-120179	￥1600.00	杭州北京（现货）
Bellancom-120179	￥2600.00	杭州北京（现货）
Bellancom-120179	￥7500.00	杭州北京（现货）
Bellancom-120179	￥12000.00	杭州北京（现货）

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LP-922761

产品介绍

LP-922761 是一种有效的，选择性的，具有口服活性的 AAK1 抑制剂，在酶和细胞分析中 IC₅₀ 分别为 4.8 nM 和 7.6 nM。LP-922761 还抑制 BMP-2 诱导蛋白激酶 (BIKE)，IC₅₀ 为 24 nM。LP-922761 对细胞 GAK，阿片类活性分子，肾上腺素 α2 或 GABAa 受体无明显活性。

生物活性

LP-922761 is a potent, selective and orally active adapter protein-2 associated kinase 1 (AAK1) inhibitor with IC₅₀s of 4.8 nM and 7.6 nM in enzyme and cell assays, respectively. LP-922761 also inhibits BMP-2-inducible protein kinase (BIKE) with an IC₅₀ of 24 nM. LP-922761 exhibits no significant activity at cyclin G-associated kinase (GAK), opioid, adrenergic α2 or GABAa receptors.

体外研究

体内研究

In mouse, LP-922761 has a brain to plasma ratio of 0.007, indicating that LP-922761 is essentially restricted to the peripheral compartment.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

In mouse, LP-922761 has a brain to plasma ratio of 0.007, indicating that LP-922761 is essentially restricted to the peripheral compartment.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : 41.67 mg/mL (101.52 mM; ultrasonic and warming and heat to 80°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.4362 mL	12.1812 mL	24.3623 mL
5 mM	0.4872 mL	2.4362 mL	4.8725 mL
10 mM	0.2436 mL	1.2181 mL	2.4362 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式