LMP744 hydrochloride MJ-III65 hydrochloride; NSC706744 hydrochloride|cas:308246-57-3|西域试剂

LMP744 hydrochloride MJ-III65 hydrochloride; NSC706744 hydrochloride,99.70%

产品编号：Bellancom-U00248A| CAS NO：308246-57-3| 分子式：C₂₄H₂₅ClN₂O₇| 分子量：488.92

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货号	价格	库存与货期
Bellancom-U00248A	￥1500.00	杭州北京（现货）
Bellancom-U00248A	￥2900.00	杭州北京（现货）
Bellancom-U00248A	￥4500.00	杭州北京（现货）
Bellancom-U00248A	￥11000.00	杭州北京（现货）

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LMP744 hydrochloride MJ-III65 hydrochloride; NSC706744 hydrochloride

产品介绍

LMP744 hydrochloride (MJ-III65 hydrochloride) 是一种 DNA 嵌和剂，是 拓扑异构酶 1 (Top1) 抑制剂，具有抗肿瘤活性。

生物活性

LMP744 hydrochloride (MJ-III65 hydrochloride) is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity.

体外研究

The GI₅₀ value of LMP744 (MJ-III-65) for NCI60 cells is 0.1 μM.
LMP744 (0.1-5 μM, 3 days) induces dose-dependent accumulation of cells in the S and G₂ phases of the cell cycle.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay

Cell Line:	P388 and P388 Top1-deficient murine leukemia cells.
Concentration:	0.1-100 μM
Incubation Time:	3 days
Result:	Induced dose-dependent accumulation of cells in the S and G₂ phases of the cell cycle.

体内研究
(In Vivo)

LMP744 (MJ-III-65) (10-50 mg/kg) administered i.v. push once a week for 4 weeks in nude mice moderately actives against human A253 and FaDu tumor xenografts without significant toxicity.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Athymic nude mice (nu/nu, female, 20-25 g, 8-12 weeks old) transplanted with A253 and FaDu human head and neck xenografts.
Dosage:	10, 25, or 50 mg/kg/week, 4 weeks
Administration:	I.V. push via tail vein
Result:	Moderately actived against human A253 and FaDu tumor xenografts without significant toxicity.

体内研究

LMP744 (MJ-III-65) (10-50 mg/kg) administered i.v. push once a week for 4 weeks in nude mice moderately actives against human A253 and FaDu tumor xenografts without significant toxicity.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Athymic nude mice (nu/nu, female, 20-25 g, 8-12 weeks old) transplanted with A253 and FaDu human head and neck xenografts.
Dosage:	10, 25, or 50 mg/kg/week, 4 weeks
Administration:	I.V. push via tail vein
Result:	Moderately actived against human A253 and FaDu tumor xenografts without significant toxicity.

体内研究

LMP744 (MJ-III-65) (10-50 mg/kg) administered i.v. push once a week for 4 weeks in nude mice moderately actives against human A253 and FaDu tumor xenografts without significant toxicity.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Athymic nude mice (nu/nu, female, 20-25 g, 8-12 weeks old) transplanted with A253 and FaDu human head and neck xenografts.
Dosage:	10, 25, or 50 mg/kg/week, 4 weeks
Administration:	I.V. push via tail vein
Result:	Moderately actived against human A253 and FaDu tumor xenografts without significant toxicity.

性状

Solid

溶解性数据

In Vitro:

DMSO : 105 mg/mL (214.76 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.0453 mL	10.2266 mL	20.4532 mL
5 mM	0.4091 mL	2.0453 mL	4.0906 mL
10 mM	0.2045 mL	1.0227 mL	2.0453 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

参考文献