S29434 NMDPEF|cas:874484-20-5|西域试剂

S29434 NMDPEF,99.25%

产品编号：Bellancom-122614| CAS NO：874484-20-5| 分子式：C₂₁H₁₈N₄O₃| 分子量：374.39

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货号	价格	库存与货期
Bellancom-122614	￥1500.00	杭州北京（现货）
Bellancom-122614	￥2500.00	杭州北京（现货）
Bellancom-122614	￥4900.00	杭州北京（现货）
Bellancom-122614	￥8300.00	杭州北京（现货）
Bellancom-122614	￥14000.00	杭州北京（现货）

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S29434 NMDPEF

产品介绍

S29434 (NMDPEF) 是一种有效、竞争性、选择性、可透过细胞膜的醌还原酶 2 (quinone reductase 2 (QR2)) 抑制剂，在不同的组织层面，对人 QR2 的 IC₅₀ 值为 5-16 nM，对其选择性高于 QR1。S29434 (NMDPEF) 可诱导自噬，抑制 QR2 介导的 ROS 的产生。

生物活性

S29434 (NMDPEF) is a potent, competitive, selective and cell-permeable inhibitor of quinone reductase 2 (QR2), with IC₅₀s ranging from 5 to 16 nM for human QR2 at different organizational levels, and has good selectivity for QR2 over QR1. S29434 induces autophagy and inhibits QR2-mediated ROS production.

体外研究

S29434 (5-10 μM; 24 h) induces HepG2 cells autophagy.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Autophagy Assay

Cell Line:	HepG2 cell line
Concentration:	5 and 10 μM
Incubation Time:	24 hours
Result:	Mitochondrial ROS-independently and QR2-dependently triggered autophagy, and dose-dependently induced LC3-II which is a marker of autophagy vesicles.

体内研究
(In Vivo)

S29434 (1 and 15 mg/kg; i.p. once) affects object recognition memory in vivo.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	CH3 wild-type mice
Dosage:	1 and 15 mg/kg
Administration:	Intraperitoneal injection; 1 and 15 mg/kg once
Result:	Positively affected memory by inhibiting QR2.

体内研究

S29434 (1 and 15 mg/kg; i.p. once) affects object recognition memory in vivo.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	CH3 wild-type mice
Dosage:	1 and 15 mg/kg
Administration:	Intraperitoneal injection; 1 and 15 mg/kg once
Result:	Positively affected memory by inhibiting QR2.

体内研究

S29434 (1 and 15 mg/kg; i.p. once) affects object recognition memory in vivo.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	CH3 wild-type mice
Dosage:	1 and 15 mg/kg
Administration:	Intraperitoneal injection; 1 and 15 mg/kg once
Result:	Positively affected memory by inhibiting QR2.

性状

Solid

溶解性数据

In Vitro:

DMSO : 19.29 mg/mL (51.52 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.6710 mL	13.3551 mL	26.7101 mL
5 mM	0.5342 mL	2.6710 mL	5.3420 mL
10 mM	0.2671 mL	1.3355 mL	2.6710 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 90% corn oil
Solubility: ≥ 1.93 mg/mL (5.16 mM); Clear solution

此方案可获得 ≥ 1.93 mg/mL (5.16 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。
以 1 mL 工作液为例，取 100 μL 19.3 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。