BT-13|cas:924537-98-4|西域试剂

BT-13,99.59%

产品编号：Bellancom-124401| CAS NO：924537-98-4| 分子式：C₂₃H₂₇F₄N₃O₄S| 分子量：517.54

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货号	价格	库存与货期
Bellancom-124401	￥2100.00	杭州北京（现货）
Bellancom-124401	￥3500.00	杭州北京（现货）
Bellancom-124401	￥11500.00	杭州北京（现货）
Bellancom-124401	￥0.00	杭州北京（现货）

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BT-13

产品介绍

BT-13 是有效的、胶质细胞源性神经营养因子 (GDNF) 受体 RET 的选择性激动剂 (独立于 GDNF 配体发挥作用)，促进体外感觉神经元神经突生长，减轻大鼠神经病变的发生。

生物活性

BT-13 is a potent and selective glial cell line-derived neurotrophic factor (GDNF) receptor RET agonist independently of GFLs, promoting neurite growth from sensory neurons in vitro and attenuates experimental neuropathy in the Rat.

体外研究

BT-13 stimulates phosphorylation of RET, as well as RET-dependent intracellular signaling, but activated neither NGF receptor TrkA nor BDNF receptor TrkB nor intracellular signaling in the absence of RET.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

BT-13 (20 and 25mg/kg in rats induced by ligation of left L5 and L6 spinal nerves) has a slight antinociceptive/antihyperalgesic effect and protected DRG neurons in rats with surgery-induced neuropathy.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Rats induced by ligation of left L5 and L6 spinal nerves.
Dosage:	5-25 mg/kg, dissolved in sesame oil containing 5% DMSO.
Administration:	Subcutaneous injections on post-surgical day 1, 3, 5, 8, 10, and 12.
Result:	20 and 25mg/kg decreased mechanical hypersensitivity and normalized expression of sensory neuron markers in dorsal root ganglia.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Rats induced by ligation of left L5 and L6 spinal nerves.
Dosage:	5-25 mg/kg, dissolved in sesame oil containing 5% DMSO.
Administration:	Subcutaneous injections on post-surgical day 1, 3, 5, 8, 10, and 12.
Result:	20 and 25mg/kg decreased mechanical hypersensitivity and normalized expression of sensory neuron markers in dorsal root ganglia.

性状

Solid

溶解性数据

In Vitro:

DMSO : 25 mg/mL (48.31 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.9322 mL	9.6611 mL	19.3222 mL
5 mM	0.3864 mL	1.9322 mL	3.8644 mL
10 mM	0.1932 mL	0.9661 mL	1.9322 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 2.5 mg/mL (4.83 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (4.83 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。
将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂： 10% DMSO 90% corn oil
Solubility: ≥ 2.5 mg/mL (4.83 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (4.83 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。