SW-100|cas:2126744-35-0|西域试剂

SW-100,99.59%

产品编号：Bellancom-115475| CAS NO：2126744-35-0| 分子式：C₁₇H₁₇ClN₂O₂| 分子量：316.78

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货号	价格	库存与货期
Bellancom-115475	￥2000.00	杭州北京（现货）
Bellancom-115475	￥2900.00	杭州北京（现货）
Bellancom-115475	￥7100.00	杭州北京（现货）
Bellancom-115475	￥12000.00	杭州北京（现货）

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SW-100

产品介绍

SW-100 是一种有效的组蛋白脱乙酰基酶 6 (HDAC6) 抑制剂，IC₅₀ 值为 2.3 nM，相对于其他 HDAC 酶，对 HDAC6 的选择性至少高 1000倍。SW-100 显著提高了跨越血脑屏障的能力。

生物活性

SW-100, a selective histone deacetylase 6 (HDAC6) inhibitor with an IC₅₀ of 2.3 nM, shows at least 1000-fold selectivity for HDAC6 relative to all other HDAC isozymes. SW-100 displays a significantly improved ability to cross the blood-brain-barrier.

体外研究

SW-100 (0.01-10 µM; 48 hours) shows obvious increase in the acetylated α-tubulin levels in a dose-dependent manner.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis

Cell Line:	HEK293 cells
Concentration:	0.01, 0.1, 1, 10 µM
Incubation Time:	48 hours
Result:	Showed obvious increase in the acetylated α-tubulin levels in a dose-dependent manner.

体内研究
(In Vivo)

SW-100 (20 mg/kg; i.p.; twice a day for two days) ameliorates several memory and learning impairments including novel object recognition, temporal ordering, and coordinate and categorical spatial processing in mouse model of Fragile X syndrome.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	8-10 weeks old C57BL/6 mice (Fmr1^-/- mice)
Dosage:	20 mg/kg
Administration:	Intraperitoneal injection; twice a day for two days
Result:	Ameliorated several memory and learning impairments including novel object recognition, temporal ordering, and coordinate and categorical spatial processing in Fmr1^-/-mice。

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	8-10 weeks old C57BL/6 mice (Fmr1^-/- mice)
Dosage:	20 mg/kg
Administration:	Intraperitoneal injection; twice a day for two days
Result:	Ameliorated several memory and learning impairments including novel object recognition, temporal ordering, and coordinate and categorical spatial processing in Fmr1^-/-mice。

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	8-10 weeks old C57BL/6 mice (Fmr1^-/- mice)
Dosage:	20 mg/kg
Administration:	Intraperitoneal injection; twice a day for two days
Result:	Ameliorated several memory and learning impairments including novel object recognition, temporal ordering, and coordinate and categorical spatial processing in Fmr1^-/-mice。

性状

Solid

溶解性数据

In Vitro:

DMSO : ≥ 125 mg/mL (394.60 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.1568 mL	15.7838 mL	31.5676 mL
5 mM	0.6314 mL	3.1568 mL	6.3135 mL
10 mM	0.3157 mL	1.5784 mL	3.1568 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 2.08 mg/mL (6.57 mM); Clear solution

此方案可获得 ≥ 2.08 mg/mL (6.57 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。
将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.08 mg/mL (6.57 mM); Clear solution

此方案可获得 ≥ 2.08 mg/mL (6.57 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。
将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
3.

请依序添加每种溶剂： 10% DMSO 90% corn oil
Solubility: ≥ 2.08 mg/mL (6.57 mM); Clear solution

此方案可获得 ≥ 2.08 mg/mL (6.57 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。
以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。