Protein deglycase DJ-1 against-1|cas:724737-74-0|西域试剂

Protein deglycase DJ-1 against-1,99.67%

产品编号：Bellancom-137262| CAS NO：724737-74-0| 分子式：C₂₄H₂₃N₃O₄| 分子量：417.46

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货号	价格	库存与货期
Bellancom-137262	￥500.00	杭州北京（现货）
Bellancom-137262	￥900.00	杭州北京（现货）
Bellancom-137262	￥1400.00	杭州北京（现货）
Bellancom-137262	￥2000.00	杭州北京（现货）

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Protein deglycase DJ-1 against-1

产品介绍

Protein deglycase DJ-1 against-1 是 DJ-1 结合化合物，依赖地靶向 DJ1。Protein deglycase DJ-1 against-1 可以穿透血脑屏障 (BBB)。Protein deglycase DJ-1 against-1 是神经保护剂，具有用于帕金森病研究的潜力。

生物活性

Protein deglycase DJ-1 against-1, a DJ-1-binding compound, dependently targets DJ1. Protein deglycase DJ-1 against-1 penetrates through the blood brain barrier (BBB). Protein deglycase DJ-1 against-1 is used as a neuroprotective agent and has the potential for Parkinson's disease research.

体外研究

体内研究

Protein deglycase DJ-1 against-1 (compound-23; 1 mg/kg; IP; pretreatment one hour; daily; for 4 days) significantly restores MPTP induced locomotion, dopaminergic neuronal cell death and dopamine content in DJ-1(+/+) mice but not in DJ-1(-/-) mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Wild-type male C57BL/6 mice at 8, 11-12 and 9-12 weeks; DJ-1-knockout male mice at 11-13 weeks
Dosage:	1 mg/kg
Administration:	IP; pretreatment one hour; daily; for 4 days
Result:	Significantly restored MPTP (30 mg/kg; IP; One hour after injection) induced locomotion, dopaminergic neuronal cell death and dopamine content in DJ-1(+/+) mice but not in DJ-1(-/-) mice.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Wild-type male C57BL/6 mice at 8, 11-12 and 9-12 weeks; DJ-1-knockout male mice at 11-13 weeks
Dosage:	1 mg/kg
Administration:	IP; pretreatment one hour; daily; for 4 days
Result:	Significantly restored MPTP (30 mg/kg; IP; One hour after injection) induced locomotion, dopaminergic neuronal cell death and dopamine content in DJ-1(+/+) mice but not in DJ-1(-/-) mice.

性状

Solid

溶解性数据

In Vitro:

DMSO : 25 mg/mL (59.89 mM; ultrasonic and adjust pH to 7 with NaOH)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.3954 mL	11.9772 mL	23.9544 mL
5 mM	0.4791 mL	2.3954 mL	4.7909 mL
10 mM	0.2395 mL	1.1977 mL	2.3954 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 2.08 mg/mL (4.98 mM); Clear solution

此方案可获得 ≥ 2.08 mg/mL (4.98 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。
将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂： 10% DMSO 90% corn oil
Solubility: ≥ 2.08 mg/mL (4.98 mM); Clear solution

此方案可获得 ≥ 2.08 mg/mL (4.98 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。
以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。