SB 243213|cas:200940-22-3|西域试剂

SB 243213,98.62%

产品编号：Bellancom-103112B| CAS NO：200940-22-3| 分子式：C₂₂H₁₉F₃N₄O₂| 分子量：428.41

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-103112B	￥900.00	杭州北京（现货）
Bellancom-103112B	￥1500.00	杭州北京（现货）
Bellancom-103112B	￥3500.00	杭州北京（现货）
Bellancom-103112B	￥6500.00	杭州北京（现货）
Bellancom-103112B	￥12000.00	杭州北京（现货）

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SB 243213

产品介绍

SB 243213 是一种口服有效的，选择性的，高亲和力的 5-HT_2C 受体拮抗剂，对人 5-HT_2C 受体的 pK_i 为 9.37，pK_b 为 9.8。SB 243213 对多种神经递质受体、酶和离子通道具有超过 100 倍的选择性。SB 243213 具有改善的抗焦虑特性，有用于精神分裂症和运动障碍的潜力。

生物活性

SB 243213 is an orally active, selective and high-affinity 5-HT_2C receptor antagonist with a pK_i of 9.37 and a pK_b of 9.8 for human 5-HT_2C receptor. SB 243213 shows greater than a 100-fold selectivity over a wide range of neurotransmitter receptors, enzymes and ion channels. SB 243213 has improved anxiolytic profile and has the potential for schizophrenia and motor disorders.

体外研究

SB 243213 shows little affinity (pK_i<6) for cloned human 5-HT_1A, 5-HT_1B, 5-HT_1E, 5- HT_1F and 5-HT₇ receptors. It shows weak affinity (pK_i<6.5) for the cloned human 5-HT_1D and D3 receptors and moderate affinity (pK_i=6.7) for the cloned human D2 receptor.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

SB 243213 (0.1-10 mg/kg, p.o. 1 h pre-test) dose-dependently and significantly increases the amount of time rats spent in social interaction over 15 min under brightly lit conditions and in an unfamiliar test box.
SB 243213 (0.3 mg/kg; p.o.; 1 h pre-test) significantly increases time spent in social interaction.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Sprague-Dawley experimentally naive rats (220-300 g)
Dosage:	0.1, 0.3, 1, 3, 10 mg/kg
Administration:	PO; 1 hour pre-test
Result:	Dose-dependently and significantly increased the amount of time rats spent in social interaction over 15 min under brightly lit conditions and in an unfamiliar test box.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Sprague-Dawley experimentally naive rats (220-300 g)
Dosage:	0.1, 0.3, 1, 3, 10 mg/kg
Administration:	PO; 1 hour pre-test
Result:	Dose-dependently and significantly increased the amount of time rats spent in social interaction over 15 min under brightly lit conditions and in an unfamiliar test box.

性状

Solid

溶解性数据

In Vitro:

DMSO : 125 mg/mL (291.78 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.3342 mL	11.6711 mL	23.3421 mL
5 mM	0.4668 mL	2.3342 mL	4.6684 mL
10 mM	0.2334 mL	1.1671 mL	2.3342 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式