p-Ethynylphenylalanine 4-Ethynyl-L-phenylalanine|cas:278605-15-5|西域试剂

p-Ethynylphenylalanine 4-Ethynyl-L-phenylalanine,99.96%

产品编号：Bellancom-23460| CAS NO：278605-15-5| 分子式：C₁₁H₁₁NO₂| 分子量：189.21

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-23460		￥1000.00	杭州北京（现货）

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p-Ethynylphenylalanine 4-Ethynyl-L-phenylalanine

产品介绍

p-Ethynylphenylalanine (4-Ethynyl-L-phenylalanine) 是一种高效、选择性的，可逆、竞争性的色氨酸羟化酶 (TPH) 抑制剂，其 K_i 值为 32.6 μM。

生物活性

p-Ethynylphenylalanine (4-Ethynyl-L-phenylalanine) is a potent, selective, reversible and competitive inhibitor of tryptophan hydroxylase (TPH), with a K_i of 32.6 μM.

体外研究

p-Ethynylphenylalanine selectively and reversibly inhibits the biosynthesis of serotonin.
p-Ethynylphenylalanine has a low affinity for various recombinant 5-HT receptors (5-HT₁, 5-HT₂, 5-HT₄, 5-HT₅, 5-HT₆, and 5-HT₇).

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

p-Ethynylphenylalanine (30 mg/kg; i.p.) decreases in 5-HT and 5-HIAA levels in the rat midbrain but not in tissue.
p-Ethynylphenylalanine does not inhibit the aromatic amino acid decarboxylase.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Sprague-Dawley rats (200 g)
Dosage:	30 mg/kg
Administration:	Intraperitoneal injection
Result:	Decreased in 5-HT and 5-HIAA levels in the rat midbrain.

体内研究

p-Ethynylphenylalanine (30 mg/kg; i.p.) decreases in 5-HT and 5-HIAA levels in the rat midbrain but not in tissue.
p-Ethynylphenylalanine does not inhibit the aromatic amino acid decarboxylase.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Sprague-Dawley rats (200 g)
Dosage:	30 mg/kg
Administration:	Intraperitoneal injection
Result:	Decreased in 5-HT and 5-HIAA levels in the rat midbrain.

性状

Solid

溶解性数据

In Vitro:

1M HCl : 240 mg/mL (1268.43 mM; ultrasonic and adjust pH to 1 with HCl)

1M NaOH : 240 mg/mL (1268.43 mM; ultrasonic and adjust pH to 11 with NaOH)

DMSO : 2.22 mg/mL (11.73 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	5.2851 mL	26.4257 mL	52.8513 mL
5 mM	1.0570 mL	5.2851 mL	10.5703 mL
10 mM	0.5285 mL	2.6426 mL	5.2851 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式