BIA 10-2474|cas:1233855-46-3|西域试剂

BIA 10-2474,99.39%

产品编号：Bellancom-19740| CAS NO：1233855-46-3| 分子式：C₁₆H₂₀N₄O₂| 分子量：300.36

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货号	价格	库存与货期
Bellancom-19740	￥600.00	杭州北京（现货）
Bellancom-19740	￥1050.00	杭州北京（现货）
Bellancom-19740	￥3750.00	杭州北京（现货）
Bellancom-19740	￥5800.00	杭州北京（现货）

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BIA 10-2474

产品介绍

BIA 10-2474是脂肪酸酰胺水解酶FAAH的抑制剂，对大鼠大脑不同区域的IC₅₀值为50至70mg/kg。

生物活性

BIA 10-2474 is an inhibitor of fatty acid amide hydrolase (FAAH) with IC₅₀ values of 50 to 70mg/kg in various rat brain regions.

体外研究

ExVivo: BIA 10-2474 proves to be a potent FAAH inhibitor with IC₅₀s of 50-70mg/kg (i.p.) in various brain regions. IC₅₀ values for brain regions are 52 (cerebellum), 67 (rest of brain), 68 (cortex), and 71 mg/kg (hypothalamus).

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

In January 2016, severe adverse events (SAE) occurs in the Phase I clinical trial using the drug BIA 10-2474 including one death. The possibilities for failure of trials such as off-target effect, dose calculation, unexpected immune response, species variation, and cumulative dose toxicity would be sought.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : 2.2 mg/mL (7.32 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.3293 mL	16.6467 mL	33.2934 mL
5 mM	0.6659 mL	3.3293 mL	6.6587 mL
10 mM	---	---	---

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式