Afizagabar S44819; Egis-13529|cas:1398496-82-6|西域试剂

Afizagabar S44819; Egis-13529,98.23%

产品编号：Bellancom-120051| CAS NO：1398496-82-6| 分子式：C₁₉H₁₂FN₃O₂S| 分子量：365.38

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货号	价格	库存与货期
Bellancom-120051	￥5000.00	杭州北京（现货）
Bellancom-120051	￥8500.00	杭州北京（现货）
Bellancom-120051	￥18000.00	杭州北京（现货）
Bellancom-120051	￥30000.00	杭州北京（现货）
Bellancom-120051	￥46000.00	杭州北京（现货）

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Afizagabar S44819; Egis-13529

产品介绍

Afizagabar (S44819) 是一种首创的，有竞争性的，选择性的 α5-GABAAR 拮抗剂，对α5β2γ2 的IC₅₀ 值 585nM，对 α5β3γ2 的 K_i 为 66 nM。Afizagabar 增强海马突触可塑性并显示促认知功效。

生物活性

Afizagabar (S44819) is a first-in-class, competitive, and selective antagonist at the GABA-binding site of the α5-GABAAR, with an IC₅₀ of 585 nM for α5β2γ2 and a K_i of 66 nM for α5β3γ2. Afizagabar enhances hippocampal synaptic plasticity and exhibits pro-cognitive efficacy.

体外研究

Afizagabar (S44819) is a competitive α5-GABAAR antagonist (Kb=221 nM). Afizagabar selectively inhibits extrasynaptic α5-GABAARs of mouse CA1 pyramidal neurons.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Afizagabar (1 and 3 mg/kg; i.p.) significantly diminishes the marked increase in total errors induced by Scopolamine.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Sprague Dawley (SPRD) rats (In the eight-arm radial maze)
Dosage:	1 and 3 mg/kg
Administration:	I.p.
Result:	Significantly diminished the marked increase in total errors induced by Scopolamine.

体内研究

Afizagabar (1 and 3 mg/kg; i.p.) significantly diminishes the marked increase in total errors induced by Scopolamine.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Sprague Dawley (SPRD) rats (In the eight-arm radial maze)
Dosage:	1 and 3 mg/kg
Administration:	I.p.
Result:	Significantly diminished the marked increase in total errors induced by Scopolamine.

性状

Solid

溶解性数据

In Vitro:

DMSO : 6.25 mg/mL (17.11 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.7369 mL	13.6844 mL	27.3688 mL
5 mM	0.5474 mL	2.7369 mL	5.4738 mL
10 mM	0.2737 mL	1.3684 mL	2.7369 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式