ABT-418 hydrochloride|cas:147388-83-8|西域试剂

ABT-418 hydrochloride,99.53%

产品编号：Bellancom-105170B| CAS NO：147388-83-8| 分子式：C₉H₁₅ClN₂O| 分子量：202.68

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货号	价格	库存与货期
Bellancom-105170B	￥1200.00	杭州北京（现货）
Bellancom-105170B	￥2000.00	杭州北京（现货）
Bellancom-105170B	￥4000.00	杭州北京（现货）
Bellancom-105170B	￥6000.00	杭州北京（现货）
Bellancom-105170B	￥8500.00	杭州北京（现货）

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ABT-418 hydrochloride

产品介绍

ABT-418 hydrochloride 是一种高效、选择性的 nAChRs 激动剂，具有增强认知和抗焦虑的作用。ABT-418hydrochloride 激活胆碱能通道，可用于阿尔茨海默病的研究。

生物活性

ABT-418 hydrochloride is a potent and selective agonist of nAChRs with cognitive enhancing and anxiolytic activities. ABT-418 hydrochloride activates cholinergic channel and can be used for research of Alzheimer's disease.

体外研究

体内研究

ABT-418 hydrochloride (125.66 μg/kg; i.p.) induces a significant increase in the time spent by the rats in the open arms of the elevated plus maze.
Acute administration of ABT-418 (125.66μg/kg; i.p.) also attenuates the anxiogenic-like effect elicited by withdrawal from chronic (-)-nicotine treatment.
ABT-418 hydrochloride (0.6 mg/kg; i.p.; daily; for two weeks) effectively improves spatial memory in an animal model of ADHD.
ABT-418 hydrochloride significantly enhances the cortical α4 and β2 nAChR subunits and the hippocampal α4 subunit expression.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male SHRs (4–5 weeks old), attention deficit hyperactivity disorder (ADHD) model
Dosage:	0.6 mg/kg
Administration:	Intraperitoneal injection; once daily; for two weeks
Result:	Effectively improved spatial memory.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male SHRs (4–5 weeks old), attention deficit hyperactivity disorder (ADHD) model
Dosage:	0.6 mg/kg
Administration:	Intraperitoneal injection; once daily; for two weeks
Result:	Effectively improved spatial memory.

性状

Solid

溶解性数据

In Vitro:

H₂O : 11.9 mg/mL (58.71 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	4.9339 mL	24.6694 mL	49.3389 mL
5 mM	0.9868 mL	4.9339 mL	9.8678 mL
10 mM	0.4934 mL	2.4669 mL	4.9339 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶