Iclepertin BI-425809|cas:1421936-85-7|西域试剂

Iclepertin BI-425809,99.65%

产品编号：Bellancom-138935| CAS NO：1421936-85-7| 分子式：C₂₀H₁₈F₆N₂O₅S| 分子量：512.42

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-138935		￥6800.00	杭州北京（现货）
Bellancom-138935		￥11000.00	杭州北京（现货）

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Iclepertin BI-425809

产品介绍

Iclepertin (BI-425809) 是一种有效、选择性且具有口服活性的甘氨酸转运蛋白 1 (GlyT1) 抑制剂。Iclepertin 对 GlyT2 无活性。Iclepertin 可用于阿尔茨海默病和精神分裂症研究。

生物活性

Iclepertin (BI-425809) is a potent, selective and orally active glycine transporter 1 (GlyT1) inhibitor. Iclepertin is inactive against GlyT2. Iclepertin can be used for Alzheimer disease and schizophrenia research.

体外研究

Iclepertin inhibits GlyT1 with the IC₅₀ values of 5.2 nM in rat primary neurons and 5.0 nM in human SK-N-MC cells.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Single oral administration of Iclepertin induced a dose-dependent increase of glycine cerebrospinal fluid (CSF) levels. Oral administration of Iclepertin in rats induced a dose‐dependent increase of glycine CSF levels from 30% (0.2 mg/kg, not significant) to 78% (2 mg/kg), relative to vehicle.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : 11.36 mg/mL (22.17 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.9515 mL	9.7576 mL	19.5152 mL
5 mM	0.3903 mL	1.9515 mL	3.9030 mL
10 mM	0.1952 mL	0.9758 mL	1.9515 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式