Secoisolariciresinol diglucoside 亚麻木酚素; (S,S-SDG; (S,S)-LGM2605)|cas:257930-74-8|西域试剂

Secoisolariciresinol diglucoside 亚麻木酚素; (S,S-SDG; (S,S)-LGM2605),99.94%

产品编号：Bellancom-105008| CAS NO：257930-74-8| 分子式：C₃₂H₄₆O₁₆| 分子量：686.70

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货号	价格	库存与货期
Bellancom-105008	￥800.00	杭州北京（现货）
Bellancom-105008	￥1400.00	杭州北京（现货）
Bellancom-105008	￥2800.00	杭州北京（现货）
Bellancom-105008	￥3900.00	杭州北京（现货）
Bellancom-105008	￥6700.00	杭州北京（现货）

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Secoisolariciresinol diglucoside 亚麻木酚素; (S,S-SDG; (S,S)-LGM2605)

产品介绍

Secoisolariciresinol diglucoside ((S,S)-SDG) 是全麦亚麻籽中的主要木脂素，具有抗炎，抗氧化，抗诱变，抗微生物，抗肥胖，降血脂和神经保护作用。

生物活性

Secoisolariciresinol diglucoside ((S,S)-SDG), the main lignan in wholegrain flaxseed, is known for its beneficial effects including anti-inflammatory, antioxidant, anti-mutagenic, anti-microbial, anti-obesity, hypolipidemic, and neuroprotective effects.

体外研究

Secoisolariciresinol diglucoside (1-500 μM) possesses strong reducing power and high free radical scavenging activity for hydroxyl, peroxyl and DPPH free radicals.
Secoisolariciresinol diglucoside (1-50 μM; 24 h) attenuates human monocyte adhesion to and migration across human brain endothelial monolayers.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Secoisolariciresinol diglucoside (4 mg/mouse; a single p.o.) diminishes leukocyte adhesion and migration across blood-brain barrier (BBB) in neuroinflammation.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Hand feeding mice (10 weeks old, male) are injected with TNFα
Dosage:	4 mg/mouse
Administration:	P.o. 2 h before i.c. administration of TNFα
Result:	Attenuated adhesion of leukocytes to the endothelium by 50% and attenuated migration of leukocytes across the BBB by 64%.

体内研究

Secoisolariciresinol diglucoside (4 mg/mouse; a single p.o.) diminishes leukocyte adhesion and migration across blood-brain barrier (BBB) in neuroinflammation.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Hand feeding mice (10 weeks old, male) are injected with TNFα
Dosage:	4 mg/mouse
Administration:	P.o. 2 h before i.c. administration of TNFα
Result:	Attenuated adhesion of leukocytes to the endothelium by 50% and attenuated migration of leukocytes across the BBB by 64%.

性状

Solid

溶解性数据

In Vitro:

H₂O : ≥ 100 mg/mL (145.62 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.4562 mL	7.2812 mL	14.5624 mL
5 mM	0.2912 mL	1.4562 mL	2.9125 mL
10 mM	0.1456 mL	0.7281 mL	1.4562 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： PBS
Solubility: 50 mg/mL (72.81 mM); Clear solution; Need ultrasonic

*以上所有助溶剂都可在西域网站选购。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

参考文献

. Mishra OP, et al. Synthesis and antioxidant evaluation of (S,S)- and (R,R)-secoisolariciresinol diglucosides (SDGs). Bioorg Med Chem Lett. 2013 Oct 1;23(19):5325-8. [Content Brief]

. Rom S, et, al. Secoisolariciresinol diglucoside is a blood-brain barrier protective and anti-inflammatory agent: implications for neuroinflammation. J Neuroinflammation. 2018 Jan 27;15(1):25. [Content Brief]

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Secoisolariciresinol diglucoside 亚麻木酚素; (S,S-SDG; (S,S)-LGM2605),99.94%

Secoisolariciresinol diglucoside 亚麻木酚素; (S,S-SDG; (S,S)-LGM2605)

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