MAO-IN-M30 dihydrochloride|cas:64821-19-8|西域试剂

MAO-IN-M30 dihydrochloride,99.25%

产品编号：Bellancom-131036| CAS NO：64821-19-8| 分子式：C₁₄H₁₆Cl₂N₂O| 分子量：299.20

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	包装	价格	库存与货期	购买量	操作
Bellancom-131036		￥4500.00	杭州北京（现货）

增值税发票√顺丰快递√订货电话：18601927057

MAO-IN-M30 dihydrochloride

产品介绍

MAO-IN-M30 dihydrochloride 是一种口服活性，可通过血脑屏障的，脑选择性不可逆 MAO-A (IC₅₀=37 nM) 和 MAO-B (IC₅₀=57 nM) 抑制剂。MAO-IN-M30 dihydrochloride 是有效的铁螯合剂、自由基清除剂。MAO-IN-M30 dihydrochloride 对 Dexamethasone 诱导的脑细胞凋亡具有神经保护作用。MAO-IN-M30 dihydrochloride 在 MPTP 和 lactacystin 帕金森病模型中也显示出神经恢复活性。

生物活性

MAO-IN-M30 dihydrochloride is an orally active, brain-permeable, and brain selective irreversible MAO-A (IC₅₀=37 nM) and MAO-B (IC₅₀=57 nM) inhibitor. MAO-IN-M30 dihydrochloride is a potent iron chelator and radical scavenger. MAO-IN-M30 dihydrochloride has a neuroprotective effect against Dexamethasone-induced brain cell apoptosis. MAO-IN-M30 dihydrochloride also exhibits neurorestorative activity in post MPTP and lactacystin models of Parkinson's disease.

体外研究

MAO-IN-M30 (0.25 nM; 72 hours) significantly increased cell viability to ~90% after exposure to Dexamethasone.
MAO-IN-M30 (0-10 μM; 24 hours) enhances PC12 cell survival^[4].
MAO-IN-M30 treatment significantly decreases the occurrence of fragmented DNA compared to the dexamethasone-treated group in SH-SY5Y cells.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line:	SH-SY5Y cells
Concentration:	0.25 nM
Incubation Time:	72 hours
Result:	Significantly increased cell viability to ∼90% after exposure to Dexamethasone.

Cell Viability Assay^[4]

Cell Line:	PC12 cells
Concentration:	0-10 μM
Incubation Time:	24 hours
Result:	Enhanced the PC12 cell viability, the cell viability increasing to 85 ± 6 and 90 ± 7%.

体内研究
(In Vivo)

MAO-IN-M30 (0.5-2.5 mg/kg; p.o.; once daily for 14 consecutive days) possesses neuroprotective activities^[6].

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male C57/BL mice (20-22 g; MPTP-induced neurotoxicity in mice)^[6]
Dosage:	0.5, 2.5 mg/kg
Administration:	P.o.; once daily for 14 consecutive days
Result:	Significantly elevate striatal dopamine levels, reduce its metabolism, and elevate tyrosine-hydroxylase protein levels and activity. Elevated MPTP-reduced dopaminergic and transferrin receptor cell count in the SNpc.

体内研究

MAO-IN-M30 (0.5-2.5 mg/kg; p.o.; once daily for 14 consecutive days) possesses neuroprotective activities^[6].

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male C57/BL mice (20-22 g; MPTP-induced neurotoxicity in mice)^[6]
Dosage:	0.5, 2.5 mg/kg
Administration:	P.o.; once daily for 14 consecutive days
Result:	Significantly elevate striatal dopamine levels, reduce its metabolism, and elevate tyrosine-hydroxylase protein levels and activity. Elevated MPTP-reduced dopaminergic and transferrin receptor cell count in the SNpc.

体内研究

MAO-IN-M30 (0.5-2.5 mg/kg; p.o.; once daily for 14 consecutive days) possesses neuroprotective activities^[6].

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male C57/BL mice (20-22 g; MPTP-induced neurotoxicity in mice)^[6]
Dosage:	0.5, 2.5 mg/kg
Administration:	P.o.; once daily for 14 consecutive days
Result:	Significantly elevate striatal dopamine levels, reduce its metabolism, and elevate tyrosine-hydroxylase protein levels and activity. Elevated MPTP-reduced dopaminergic and transferrin receptor cell count in the SNpc.

性状

Solid

溶解性数据

In Vitro:

DMSO : 2 mg/mL (6.68 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.3422 mL	16.7112 mL	33.4225 mL
5 mM	0.6684 mL	3.3422 mL	6.6845 mL
10 mM	---	---	---

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

参考文献