UNC9994 hydrochloride,98.83%
产品编号：Bellancom-111385| CAS NO：2108826-33-9| 分子式：C21H23Cl3N2OS| 分子量：457.84
本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，
UNC9994 hydrochloride
| 产品介绍 | UNC9994 hydrochloride 是一种功能选择性的 β-arrestin 偏向的多巴胺 D2 受体 (D2R) 激动剂，可选择性激活 β- arresttin 招募和信号转导。对 D2R 的 Ki 值为 79 nM。UNC9994 hydrochloride 也是 Gi 调节 cAMP 产生的拮抗剂和 D2R/β-arrestin-2 相互作用的部分激动剂。UNC9994 hydrochloride 具有稳定精神效果。 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 生物活性 | UNC9994 hydrochloride is a functionally selective, β-arrestin–biased dopamine D2 receptor (D2R) agonist that selectively activates β-arrestin recruitment and signaling. UNC9994 hydrochloride shows a binding affinity with a Ki of 79 nM for D2R. UNC9994 hydrochloride is also an antagonist of Gi-regulated cAMP production and partial agonist for D2R/β-arrestin-2 interactions. UNC9994 hydrochloride shows antipsychotic-like activity. | ||||||||
| 体外研究 |
UNC9994 hydrochloride induces D2-mediated β-arrestin-2 translocation with an EC50s of 6.1 nM and 448 nM in Tango assay and DiscoveRx assay, respectively. 西域 has not independently confirmed the accuracy of these methods. They are for reference only. | ||||||||
| 体内研究 |
UNC9994 (2.0 mg/kg; i.p.; once) hydrochloride shows antipsychotic activity that is attenuated in β-arrestin-2 knockout mice. 西域 has not independently confirmed the accuracy of these methods. They are for reference only.
| ||||||||
| 体内研究 |
UNC9994 (2.0 mg/kg; i.p.; once) hydrochloride shows antipsychotic activity that is attenuated in β-arrestin-2 knockout mice. 西域 has not independently confirmed the accuracy of these methods. They are for reference only.
| ||||||||
| 性状 | Solid | ||||||||
| 溶解性数据 | |||||||||
| 运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||
| 储存方式 |
4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) | ||||||||
| 参考文献 |
浙公网安备 33010802013016号