MC180295 (rel-MC180295)|cas:2237942-08-2|西域试剂

MC180295 (rel-MC180295),98.41%

产品编号：Bellancom-119940| CAS NO：2237942-08-2| 分子式：C₁₇H₁₈N₄O₃S| 分子量：358.41

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-119940	￥2200.00	杭州北京（现货）
Bellancom-119940	￥3550.00	杭州北京（现货）
Bellancom-119940	￥6650.00	杭州北京（现货）
Bellancom-119940	￥11700.00	杭州北京（现货）

增值税发票√顺丰快递√订货电话：18601927057

MC180295 (rel-MC180295)

产品介绍

MC180295 ((rel)-MC180295) 是一种有效、选择性的 CDK9-Cyclin T1 抑制剂，IC₅₀ 值为 5 nM，对其选择性至少是对其他 CDK 激酶 22 倍。MC180295 ((rel)-MC180295) 同时抑制 GSK-3α 和 GSK-3β。MC180295 具有的抗肿瘤活性。

生物活性

MC180295 ((rel)-MC180295) is a potent and selective CDK9-Cyclin T1 inhibitor, with an IC₅₀ of 5 nM, at least 22-fold more selective for CDK9 over other CDKs. MC180295 also inhibits GSK-3α and GSK-3β. MC180295 ((rel)-MC180295) has potent anti-tumor effect.

体外研究

MC180295 is a potent and selective CDK9-Cyclin T1 inhibitor, with an IC₅₀ of 5 nM, at least 22-fold more selective for CDK9 over other CDKs, such as CDK1-Cyclin B (IC₅₀, 138 nM), CDK2-Cyclin A (IC₅₀, 233 nM), CDK2-Cyclin E (IC₅₀, 367 nM), CDK3-Cyclin E (IC₅₀, 399 nM), CDK4-Cyclin D (IC₅₀, 112 nM), CDK5-P35 (IC₅₀, 159 nM), CDK5-P25 (IC₅₀, 186 nM), CDK6-Cyclin D3 (IC₅₀, 712 nM), and CDK7-CycH/MAT1 (IC₅₀, 555 nM). MC180295 also inhibits GSK-3α and GSK-3β.
MC180295 (500 nM) reactivates epigenetically silenced genes by targeting CDK9 without affecting DNA methylation.
MC180295 (0.1 μM) inhibits the proliferation in cancer cells.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

MC180295 (20 mg/kg, i.p., qod) inhibits significant anti-tumor activity in mice bearing SW48 cells, shows no inhibitory activity against human T cell growth in vivo.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

MC180295 (20 mg/kg, i.p., qod) inhibits significant anti-tumor activity in mice bearing SW48 cells, shows no inhibitory activity against human T cell growth in vivo.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : 100 mg/mL (279.01 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.7901 mL	13.9505 mL	27.9010 mL
5 mM	0.5580 mL	2.7901 mL	5.5802 mL
10 mM	0.2790 mL	1.3951 mL	2.7901 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

参考文献