Tolterodine 托特罗定; (R-(+)-Tolterodine; (+)-Tolterodine; (R)-Tolterodine; PNU-200583),99.55%
产品编号:Bellancom-A0024| CAS NO:124937-51-5| 分子式:C22H31NO| 分子量:325.49
Tolterodine(PNU-200583)是毒蕈碱型受体(mAChR)拮抗剂。
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Tolterodine 托特罗定; (R-(+)-Tolterodine; (+)-Tolterodine; (R)-Tolterodine; PNU-200583)
产品介绍 | Tolterodine(PNU-200583)是毒蕈碱型受体(mAChR)拮抗剂。 | ||||||||||||||||
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生物活性 | Tolterodine(PNU-200583) is a potent muscarinic receptor antagonists that show selectivity for the urinary bladder over salivary glands in vivo. IC50 Value: Target: mAChR in vitro: Carbachol-induced contractions of isolated guinea pig bladder were effectively inhibited by tolterodine (IC50 14 nM) and 5-HM (IC50 5.7 nM). The IC50 values were in the microM range and the antimuscarinic potency of tolterodine was 27, 200 and 370-485 times higher, respectively, than its potency in blocking histamine receptors, alpha-adrenoceptors and calcium channels. The active metabolite, 5-HM, was >900 times less potent at these sites than at bladder muscarinic receptors . in vivo: Tolterodine was extensively metabolized in vivo . In the passive-avoidance test, tolterodine at 1 or 3 mg/kg had no effect on memory; the latency to cross and percentage of animals crossing were comparable to controls. In contrast, scopolamine induced a memory deficit; the latency to cross was decreased, and the number of animals crossing was increased . | ||||||||||||||||
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性状 | Oil | ||||||||||||||||
溶解性数据 |
In Vitro:
Ethanol : 120 mg/mL (368.67 mM; Need ultrasonic) DMSO : 100 mg/mL (307.23 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:
——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
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运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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参考文献 |
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危害码 (欧洲) | Xn,Xi |
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风险声明 (欧洲) | R22:Harmful if swallowed. |
安全声明 (欧洲) | S36/37/39 |
危险品运输编码 | 1987 |
WGK德国 | 2 |
上游产品 7 | |
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下游产品 2 | |

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