PF-06648671
产品编号：Bellancom-120789| CAS NO：1587727-31-8| 分子式：C25H23ClF4N4O3| 分子量：538.92
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PF-06648671
| 产品介绍 | PF-06648671 是一种新型的，可通透血脑屏障的，具有口服活性的 γ 分泌酶 (γ‐Secretase) 调节剂 (GSM)。PF-06648671 减少 Aβ42 和 Aβ40，并且伴随 Aβ37 和 Aβ38 的增加。PF-06648671 用于阿尔茨海默病的研究。 | |||||||||
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| 生物活性 | PF-06648671 is a novel, brain-penetrable, and orally active γ-secretase modulator (GSM). PF-06648671 reduces Aβ42 and Aβ40, with concomitant increases in Aβ37 and Aβ38 in vitro. PF-06648671 is used for the study of Alzheimer’s disease. | |||||||||
| 体外研究 |
In a cell-based assay, PF-06648671 reduces Aβ42 and Aβ40 , with concomitant increases in Aβ37 and Aβ38, without inhibiting the cleavage of Notch or other substrates. 西域 has not independently confirmed the accuracy of these methods. They are for reference only. | |||||||||
| 体内研究 |
PF-06648671 demonstrates reduces Aβ42 within the brain and CSF following acute oral administration in animals. 西域 has not independently confirmed the accuracy of these methods. They are for reference only. | |||||||||
| 体内研究 |
PF-06648671 demonstrates reduces Aβ42 within the brain and CSF following acute oral administration in animals. 西域 has not independently confirmed the accuracy of these methods. They are for reference only. | |||||||||
| 性状 | Solid | |||||||||
| 溶解性数据 | ||||||||||
| 运输条件 | Room temperature in continental US; may vary elsewhere. | |||||||||
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| 参考文献 |
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