Tominersen RG6042; IONIS-HTTRx,97.34%

产品编号:Bellancom-132579| CAS NO:1709886-74-7| 分子量:7078.00

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用,

货号 包装 价格 库存与货期 购买量 操作
Bellancom-132579
7600.00 杭州 北京(现货)
Bellancom-132579
16800.00 杭州 北京(现货)

增值税发票√顺丰快递√订货电话:18601927057

Tominersen RG6042; IONIS-HTTRx

产品介绍 Tominersen (RG6042) 是第二代 2′-O-(2-甲氧基乙基) 反义寡核苷酸,靶向亨廷蛋白 (HTT) mRNA,有效抑制 HTT 的合成。Tominersen 能在小鼠中提高存活率并减少脑萎缩。Tominersen 可用于亨廷顿病 (HD) 的研究。
生物活性

Tominersen (RG6042) is a second-generation 2′-O-(2-methoxyethyl) antisense oligonucleotide that targets huntingtin protein (HTT) mRNA and potently suppresses HTT production. Tominersen improves survival and reduces brain atrophy in mice. Tominersen can be used for the research of Huntington’s disease (HD).

体外研究

Tominersen binds to its cognate mRNA by means of Watson-Crick base-pair interactions, triggering RNase H1-mediated degradation of the target mRNA.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Tominersen can be detected in the neurons of most brain regions, including the frontal cortex, striatum, thalamus, midbrain, brainstem and cerebellum after delivering into the CNS.
Tominersen effectively suppresses huntingtin accumulation, and generates sustained phenotypic reversal in HD-like disease after transient huntingtin reduction in rodents.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Tominersen can be detected in the neurons of most brain regions, including the frontal cortex, striatum, thalamus, midbrain, brainstem and cerebellum after delivering into the CNS.
Tominersen effectively suppresses huntingtin accumulation, and generates sustained phenotypic reversal in HD-like disease after transient huntingtin reduction in rodents.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状Solid
溶解性数据
In Vitro: 

H2O : 50 mg/mL (7.06 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.1413 mL 0.7064 mL 1.4128 mL
5 mM 0.0283 mL 0.1413 mL 0.2826 mL
10 mM --- --- ---
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

参考文献

相关文档

化学品安全说明书(MSDS)

下载MSDS

质检证书(COA)

相关产品


服务热线

13911702513
18601927057

微信客服