BW-180C [D-Ala2, D-Leu5]-Enkephalin; DADLE|cas:63631-40-3|西域试剂

BW-180C [D-Ala2, D-Leu5]-Enkephalin; DADLE,99.65%

产品编号：Bellancom-105343| CAS NO：63631-40-3| 分子式：C₂₉H₃₉N₅O₇| 分子量：569.65

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货号	价格	库存与货期
Bellancom-105343	￥770.00	杭州北京（现货）
Bellancom-105343	￥1200.00	杭州北京（现货）
Bellancom-105343	￥2400.00	杭州北京（现货）
Bellancom-105343	￥3900.00	杭州北京（现货）
Bellancom-105343	￥5900.00	杭州北京（现货）

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BW-180C [D-Ala2, D-Leu5]-Enkephalin; DADLE

产品介绍

BW-180C ([D-Ala2, D-Leu5]-Enkephalin) 是水溶性的多肽类阿片受体 (Opioid Receptor) 激动剂。

生物活性

BW-180C ([D-Ala2, D-Leu5]-Enkephalin) is a water soluble Opioid Receptor peptide agonist.

体外研究

BW-180C ([D-Ala2, D-Leu5]-Enkephalin) significantly inhibits cellular transcription in SH-SY5Y cells without causing cell injury. Following recovery for 72 h without BW-180C in primary neurons, the transcriptional activity fully resumes.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line:	Human neuroblastoma cells, SH-SY5Y cells
Concentration:	100 pM to 10 μM
Incubation Time:	24-72 hours
Result:	Significantly inhibited cellular transcription.

Western Blot Analysis

Cell Line:	Primary cortical neurons
Concentration:	100 nM
Incubation Time:	72 hours
Result:	Treatment significantly decreased phosphorylation of RNA polymerase II at both Ser 2 and Ser 5.

体内研究
(In Vivo)

BW-180C ([D-Ala2, D-Leu5]-Enkephalin) protects against I-R injury in hepatocytes, but not in the sinusoidal endothelial cells of the liver in rats. GPT levels are significantly lower in the BW-180C group as compared to those of the Control group, but the serum levels of HA are not different between the two groups. The concentrations of MDA of the liver tissue are significantly lower in the BW-180C group than in the Control group. BW-180C (DADLE)-induced analgesia is mediated by the stimulation of both mu- and delta-opioid receptors.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Wistar rats weighing 200 to 250 g
Dosage:	5 mg/kg
Administration:	Administered intravenously into the inferior vena cava
Result:	After 120 min of reperfusion, the serum GPT levels were significantly lower in the DADLE group than in the Control group.

Animal Model:	Male C57BL/6 mice (age, 35-42 days; weight, 18-22 g; 6 mice in each group)
Dosage:	5 mg/kg
Administration:	Injected intraperitoneally 15 min prior to I/R
Result:	The serum levels of AST and ALT in the serum DADLE group were significantly lower.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Wistar rats weighing 200 to 250 g
Dosage:	5 mg/kg
Administration:	Administered intravenously into the inferior vena cava
Result:	After 120 min of reperfusion, the serum GPT levels were significantly lower in the DADLE group than in the Control group.

Animal Model:	Male C57BL/6 mice (age, 35-42 days; weight, 18-22 g; 6 mice in each group)
Dosage:	5 mg/kg
Administration:	Injected intraperitoneally 15 min prior to I/R
Result:	The serum levels of AST and ALT in the serum DADLE group were significantly lower.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Wistar rats weighing 200 to 250 g
Dosage:	5 mg/kg
Administration:	Administered intravenously into the inferior vena cava
Result:	After 120 min of reperfusion, the serum GPT levels were significantly lower in the DADLE group than in the Control group.

Animal Model:	Male C57BL/6 mice (age, 35-42 days; weight, 18-22 g; 6 mice in each group)
Dosage:	5 mg/kg
Administration:	Injected intraperitoneally 15 min prior to I/R
Result:	The serum levels of AST and ALT in the serum DADLE group were significantly lower.

性状

Solid

溶解性数据

In Vitro:

DMSO : ≥ 300 mg/mL (526.64 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.7555 mL	8.7773 mL	17.5546 mL
5 mM	0.3511 mL	1.7555 mL	3.5109 mL
10 mM	0.1755 mL	0.8777 mL	1.7555 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

参考文献

. Jie Tian, et al. [D-Ala2, D-Leu5] encephalin (DADLE) reversibly inhibits cellular transcription in neurons without causing cell injury. Brain Res. 2014 May 27;1565:1-7. [Content Brief]

. Kousyou Yamanouchi, et al. [D-Ala2, D-Leu5] enkephalin (DADLE) protects liver against ischemia-reperfusion injury in the rat. J Surg Res. 2003 Sep;114(1):72-7. [Content Brief]

. Yi Zhou, et al. DADLE improves hepatic ischemia/reperfusion injury in mice via activation of the Nrf2/HO1 pathway. Mol Med Rep. 2017 Nov;16(5):6214-6221. [Content Brief]

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产品编号(Item Number)

批号(Lot Number)

BW-180C [D-Ala2, D-Leu5]-Enkephalin; DADLE,99.65%

BW-180C [D-Ala2, D-Leu5]-Enkephalin; DADLE

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