AZD-8529 mesylate,99.63%
产品编号:Bellancom-107457A| CAS NO:1314217-69-0| 分子式:C25H28F3N5O6S| 分子量:583.58
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AZD-8529 mesylate
产品介绍 | AZD-8529 mesylate 是一种有效的,高度选择性的,可口服的 mGluR2 正向调节剂,EC50 值为 285 nM;在 20-25 M 的浓度范围内,对 mGluR1,3,4,5,6,7 和 8 没有正向调节作用。 | ||||||||||||||||
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生物活性 | AZD-8529 mesylate is a potent, highly selective and orally bioavailable positive allosteric modulator of mGluR2, with an EC50 of 285 nM, and shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 subtypes. | ||||||||||||||||
体外研究 |
AZD-8529 mesylate potentiates the effects of glutamate at mGluR2 with an EC50 of 195 nM . 西域 has not independently confirmed the accuracy of these methods. They are for reference only. | ||||||||||||||||
体内研究 |
AZD-8529 mesylate (0.3-mg/kg, i.m.) reduces nicotine priming-induced and cue-induced reinstatement in squirrel monkeys. 西域 has not independently confirmed the accuracy of these methods. They are for reference only.
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体内研究 |
AZD-8529 mesylate (0.3-mg/kg, i.m.) reduces nicotine priming-induced and cue-induced reinstatement in squirrel monkeys. 西域 has not independently confirmed the accuracy of these methods. They are for reference only.
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性状 | Solid | ||||||||||||||||
溶解性数据 |
In Vitro:
DMSO : 41.67 mg/mL (71.40 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:
——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
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运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) | ||||||||||||||||
参考文献 |