2-Methoxyidazoxan monohydrochloride RX821002 hydrochloride,99.20%
产品编号:Bellancom-103197| CAS NO:109544-45-8| 分子式:C12H15ClN2O3| 分子量:270.71
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2-Methoxyidazoxan monohydrochloride RX821002 hydrochloride
产品介绍 | 2-Methoxyidazoxan monohydrochloride (RX821002 hydrochloride) 是一种高选择性 alpha 2r 肾上腺素受体拮抗剂,对 imidazoline拮抗作用很小或没有。2-Methoxyidazoxan monohydrochloride 对 (豚鼠) alpha 2D 肾上腺素受体 (pKd 9.7) 的亲和力明显高于 (兔子) alpha 2A 肾上腺素受体 (pKd 8.2)。 | ||||||||||||||||
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生物活性 | 2-Methoxyidazoxan monohydrochloride (RX821002 hydrochloride) is a highly selective alpha 2-adrenoceptor antagonist with little or no imidazoline antagonist effect. RX 821002 has markedly higher affinity for (guinea-pig) alpha 2D-adrenoceptors (pKd 9.7) than for (rabbit) alpha 2A-adrenoceptors (pKd 8.2). | ||||||||||||||||
体外研究 | |||||||||||||||||
体内研究 |
2-Methoxyidazoxan monohydrochloride (1 mg/kg) enhances locomotion in the novel environment, particularly in neonatal ventral hippocampal lesion (NVHL) rats. RX82100 has a biphasic effect on locomotion, consisting of an initial reduction preceding the enhancement. 西域 has not independently confirmed the accuracy of these methods. They are for reference only. | ||||||||||||||||
体内研究 |
2-Methoxyidazoxan monohydrochloride (1 mg/kg) enhances locomotion in the novel environment, particularly in neonatal ventral hippocampal lesion (NVHL) rats. RX82100 has a biphasic effect on locomotion, consisting of an initial reduction preceding the enhancement. 西域 has not independently confirmed the accuracy of these methods. They are for reference only. | ||||||||||||||||
性状 | Solid | ||||||||||||||||
溶解性数据 |
In Vitro:
H2O : 100 mg/mL (369.40 mM; Need ultrasonic) 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:
——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
*以上所有助溶剂都可在 西域 网站选购。
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运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
4°C, stored under nitrogen, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture) | ||||||||||||||||
参考文献 |
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