RSVA405|cas:140405-36-3|西域试剂

RSVA405,99.58%

产品编号：Bellancom-103238| CAS NO：140405-36-3| 分子式：C₁₇H₂₀N₄O₂| 分子量：312.37

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货号	价格	库存与货期
Bellancom-103238	￥1100.00	杭州北京（现货）
Bellancom-103238	￥1800.00	杭州北京（现货）
Bellancom-103238	￥4000.00	杭州北京（现货）
Bellancom-103238	￥7000.00	杭州北京（现货）
Bellancom-103238	￥11500.00	杭州北京（现货）

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RSVA405

产品介绍

RSVA405 是一种有效和具有口服活性的 AMPK 激活剂，EC₅₀ 值为 1 μM。RSVA405 通过促进 CaMKKβ 依赖的 AMPK 活化，从而抑制 mTOR，并促进自噬 (autophagy) 以增加 Aβ 的降解。RSVA405 通过抑制 STAT3 功能具有抗炎作用。RSVA405 也可用于肥胖症的研究。

生物活性

RSVA405 is a potent, orally active activator of AMPK, with an EC₅₀ of 1 μM. RSVA405 facilitates CaMKKβ-dependent activation of AMPK, inhibits mTOR, and promotes autophagy to increase Aβ degradation. RSVA405 has anti-inflammatory effects through the inhibition of STAT3 function. RSVA405 can also be used for the research of obesity^[4].

体外研究

RSVA405 (0.2-2 μM; 24 h) inhibits adipocyte differentiation.
RSVA405 (0.2-2 μM; 24 h) significantly inhibits the expression of peroxisome proliferator-activated receptor (PPAR)-γ, fatty acid synthase (FAS) and fatty acid binding protein 4 (aP2) in 3T3-L1 cells.
RSVA405 (1-3 μM; 16 h) inhibits LPS-induced STAT3 activity, intracellular signaling, and cytokine response in activated RAW 264.7 macrophages.
RSVA405 (1-3 μM; 24 h) inhibits mTOR, induces autophagy, and facilitates the lysosomal degradation of Aβ, with an EC₅₀ of ∼1 μM in APP-HEK293 cells^[4].

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line:	3T3-L1 preadipocytes
Concentration:	0.2, 0.5, 1, 2 μM
Incubation Time:	24 h
Result:	Increased the phosphorylation of AMPK and its substrate acetyl-CoA carboxylase (ACC). Inhibited the accumulation of lipid droplets in a dose-dependent manner, with an IC₅₀ of 0.5 μM.

体内研究
(In Vivo)

RSVA405 (3 mg/kg; i.p.) attenuates renal injury and protects renal function after ischemia-reperfusion (I/R) in rats.
RSVA405 (20-100 mg/kg/d; p.o. for 11 weeks) significantly reduces the body weight gain of mice fed a high-fat diet.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Sprague-Dawley rats (300-350 g) are induced I/R injury
Dosage:	3 mg/kg
Administration:	I.p. one hour before inducing I/R injury
Result:	Decreased the levels of creatinine and blood urea nitrogen (BUN), by 35.8% and 44.3% in serum, respectively. Decreased the levels of aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) by 33.0% and 59.8% in serum, respectively.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Sprague-Dawley rats (300-350 g) are induced I/R injury
Dosage:	3 mg/kg
Administration:	I.p. one hour before inducing I/R injury
Result:	Decreased the levels of creatinine and blood urea nitrogen (BUN), by 35.8% and 44.3% in serum, respectively. Decreased the levels of aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) by 33.0% and 59.8% in serum, respectively.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Sprague-Dawley rats (300-350 g) are induced I/R injury
Dosage:	3 mg/kg
Administration:	I.p. one hour before inducing I/R injury
Result:	Decreased the levels of creatinine and blood urea nitrogen (BUN), by 35.8% and 44.3% in serum, respectively. Decreased the levels of aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) by 33.0% and 59.8% in serum, respectively.

性状

Solid

溶解性数据

In Vitro:

DMSO : 125 mg/mL (400.17 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.2013 mL	16.0067 mL	32.0133 mL
5 mM	0.6403 mL	3.2013 mL	6.4027 mL
10 mM	0.3201 mL	1.6007 mL	3.2013 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式