MY33-3 hydrochloride|cas:2204280-42-0|西域试剂

MY33-3 hydrochloride,99.40%

产品编号：Bellancom-123966A| CAS NO：2204280-42-0| 分子式：C₁₆H₁₄ClF₆NS₂| 分子量：433.86

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货号	价格	库存与货期
Bellancom-123966A	￥3200.00	杭州北京（现货）
Bellancom-123966A	￥5100.00	杭州北京（现货）
Bellancom-123966A	￥10500.00	杭州北京（现货）

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MY33-3 hydrochloride

产品介绍

MY33-3 hydrochloride 是一种有效和选择性的蛋白酪氨酸磷酸酶 RPTPβ/ζ 抑制剂，IC₅₀ 值为 ~0.1 μM。MY33-3 hydrochloride 还抑制 PTP-1B (IC₅₀ ~0.7 μM)。MY33-3 hydrochloride 可以减少乙醇消耗并缓解 Sevoflurane 引起的神经炎症和认知功能障碍。

生物活性

MY33-3 hydrochloride is a potent and selective inhibitor of receptor protein tyrosine phosphatase (RPTP)β/ζ, with an IC₅₀ of ~0.1 μM. MY33-3 hydrochloride also inhibits PTP-1B (IC₅₀ ~0.7 μM). MY33-3 hydrochloride can reduce ethanol consumption and alleviate Sevoflurane-induced neuroinflammation and cognitive dysfunction.

体外研究

MY33-3 hydrochloride (1 μM; pretreated for 5 min) blocks Ethanol-induced activation of TrkA and ALK in SH-SY5Y cells.
MY33-3 hydrochloride (0.1-10 μM; 24 h) limits LPS-induced nitrites production and iNos increases in BV2 microglial cells.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

MY33-3 hydrochloride (60 mg/kg; p.o. on days 3 and 4) reduces ethanol consumption when comparing day 2 with day 3. MY33-3 hydrochloride reduces preference for the ethanol solution on day 3.
MY33-3 hydrochloride (i.p.) reverses the Sevoflurane-induced decrease in the discrimination index and impaired motor learning ability.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : 25 mg/mL (57.62 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.3049 mL	11.5245 mL	23.0489 mL
5 mM	0.4610 mL	2.3049 mL	4.6098 mL
10 mM	0.2305 mL	1.1524 mL	2.3049 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

参考文献