GW604714X|cas:853953-65-8|西域试剂

GW604714X,98.10%

产品编号：Bellancom-138559| CAS NO：853953-65-8| 分子式：C₂₁H₁₈FN₅O₅S| 分子量：471.46

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货号	价格	库存与货期
Bellancom-138559	￥3500.00	杭州北京（现货）
Bellancom-138559	￥5800.00	杭州北京（现货）
Bellancom-138559	￥11000.00	杭州北京（现货）
Bellancom-138559	￥17000.00	杭州北京（现货）
Bellancom-138559	￥25000.00	杭州北京（现货）

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GW604714X

产品介绍

GW604714X 是一种有效的线粒体呼吸 (mitochondrial respiration) 抑制剂。GW604714X 是一种高度特异性的线粒体丙酮酸载体 (MPC) 抑制剂，K_i <0.1 nM。GW604714X 也能抑制质膜单羧酸转运体 (MCT1) 的 L-乳酸转运，但浓度比 MPC 的大 4 个数量级。

生物活性

GW604714X is a potent inhibitor of mitochondrial respiration supported by pyruvate but not other substrates. GW604714X is a highly specific mitochondrial pyruvate carrier (MPC) inhibitor with a K_i <0.1 nM. GW604714X also inhibits L-lactate transport by the plasma membrane monocarboxylate transporter (MCT1), but at concentrations more than 4 orders of magnitude greater than the MPC.

体外研究

GW604714X inhibits the mitochondrial pyruvate carrier (MPC) with K_i value <0.1 μM in direct measurement of pyruvate transport into rat liver and yeast mitochondria.
Inhibitor titrations of pyruvate-dependent respiration by heart mitochondria gave values for the concentration of inhibitor binding sites and their K_i (nM) of 56.0 nM and 0.057 nM for the GW604714X.
GW604714X inhibits the transport of 0.5 mM [¹⁴C]-l-lactate into rat red blood cells, mediated by the monocarboxylate transporter MCT1. GW604714X at 10 μM reduces the initial rate of uptake to 30% of control values.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

性状

Solid

溶解性数据

In Vitro:

DMF : 5.26 mg/mL (11.16 mM; Need ultrasonic and warming)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.1211 mL	10.6054 mL	21.2107 mL
5 mM	0.4242 mL	2.1211 mL	4.2421 mL
10 mM	0.2121 mL	1.0605 mL	2.1211 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式